Glycosaminoglycan Conjugation for Improving the Duration of Therapeutic Action of Glucagon-Like Peptide-1

[Image: see text] Glucagon-like peptide-1 (GLP-1) is an incretin peptide that plays a crucial role in lowering blood glucose levels and holds promise for treating type II diabetes. In this study, we synthesized GLP-1 derivatives that were conjugated with glycosaminoglycans (GAGs), i.e., chondroitin...

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Detalles Bibliográficos
Autores principales: Ichikawa, Megumi, Hirayama, Tetsuya, Fukushima, Masanobu, Kitazawa, Ikue, Kojima, Kazuhiro, Sakai, Tokiko, Takatsu, Yoshihiro, Ohtaki, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044901/
https://www.ncbi.nlm.nih.gov/pubmed/30023916
http://dx.doi.org/10.1021/acsomega.8b00467

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