In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene

[Image: see text] Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III(1)), that is, “Pu27”, which is localized in the promoter region. Ligand-indu...

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Detalles Bibliográficos
Autores principales: Bhat, Jyotsna, Mondal, Soma, Sengupta, Pallabi, Chatterjee, Subhrangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044917/
https://www.ncbi.nlm.nih.gov/pubmed/30023722
http://dx.doi.org/10.1021/acsomega.6b00531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044917/
https://www.ncbi.nlm.nih.gov/pubmed/30023722
http://dx.doi.org/10.1021/acsomega.6b00531

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