Cargando…

In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene

[Image: see text] Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III(1)), that is, “Pu27”, which is localized in the promoter region. Ligand-indu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhat, Jyotsna, Mondal, Soma, Sengupta, Pallabi, Chatterjee, Subhrangsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044917/ https://www.ncbi.nlm.nih.gov/pubmed/30023722 http://dx.doi.org/10.1021/acsomega.6b00531

Ejemplares similares

Targeting Oncogene Promoters and Ribosomal RNA Biogenesis by G-Quadruplex Binding Ligands Translate to Anticancer Activity
por: Venkata Suseela, Yelisetty, et al.
Publicado: (2021)

Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions
por: Jana, Jagannath, et al.
Publicado: (2017)

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells
por: Sengupta, Pallabi, et al.
Publicado: (2018)

LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness
por: Jana, Samarjit, et al.
Publicado: (2017)

Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene
por: Stump, Sascha, et al.
Publicado: (2018)

Wild-type p53 binds to MYC promoter G-quadruplex
por: Petr, Marek, et al.
Publicado: (2016)

Effects of G-Quadruplex-Binding Plant Secondary Metabolites on c-MYC Expression
por: Zenkov, Roman G., et al.
Publicado: (2022)

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression
por: Felsenstein, Kenneth M., et al.
Publicado: (2015)

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
por: Tong, Xiaotian, et al.
Publicado: (2011)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability
por: Mathad, Raveendra I., et al.
Publicado: (2011)

Effect of Ionic Strength on Porphyrin Drugs Interaction with Quadruplex DNA Formed by the Promoter Region of C-myc and Bcl2 Oncogenes
por: Nagesh, Narayana, et al.
Publicado: (2009)

Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi
por: Psaras, Alexandra Maria, et al.
Publicado: (2021)

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy
por: Bahls, Bárbara, et al.
Publicado: (2023)

An In Silico Study of the Differential Effect of Oxidation on Two Biologically Relevant G-Quadruplexes: Possible Implications in Oncogene Expression
por: Stebbeds, William J. D., et al.
Publicado: (2012)

Nanomechanics of G-quadruplexes within the promoter of the KIT oncogene
por: Buglione, Enrico, et al.
Publicado: (2021)

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium
por: Kundu, Nikita, et al.
Publicado: (2022)

In silico direct folding of thrombin-binding aptamer G-quadruplex at all-atom level
por: Yang, Changwon, et al.
Publicado: (2017)

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin
por: Greco, Francesca, et al.
Publicado: (2022)

Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands
por: Hasegawa, Hijiri, et al.
Publicado: (2021)

Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy
por: Yuan, Libo, et al.
Publicado: (2013)

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
por: Temime-Smaali, Nassima, et al.
Publicado: (2009)

Evaluating Molecular Docking Software for Small Molecule Binding to G-Quadruplex DNA
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
por: Neidle, Stephen
Publicado: (2021)

Modulating the G‐Quadruplex and Duplex DNA Binding by Controlling the Charge of Fluorescent Molecules
por: Gil‐Martínez, Ariadna, et al.
Publicado: (2022)

G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53
por: Saha, Taniya, et al.
Publicado: (2016)

Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
por: He, Lei, et al.
Publicado: (2018)

Corrigendum: Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy
por: Yuan, Libo, et al.
Publicado: (2016)

Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule
por: Welsh, Sarah J., et al.
Publicado: (2013)

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**
por: Yangyuoru, Philip M, et al.
Publicado: (2015)

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**
por: Yangyuoru, Philip M, et al.
Publicado: (2015)

Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects
por: Sengupta, Antara, et al.
Publicado: (2019)

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma
por: Gaikwad, Snehal M., et al.
Publicado: (2020)

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
por: Keller, Josephine Geertsen, et al.
Publicado: (2022)

Putative HIV and SIV G-Quadruplex Sequences in Coding and Noncoding Regions Can Form G-Quadruplexes
por: Krafčíková, Petra, et al.
Publicado: (2017)

Stability of the Na(+) Form of the Human Telomeric G-Quadruplex: Role of Adenines in Stabilizing G-Quadruplex Structure
por: Tucker, Brenna A., et al.
Publicado: (2018)

Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA
por: Andréasson, Måns, et al.
Publicado: (2022)

Towards Computational Modeling of Ligand Binding to the ILPR G-Quadruplex
por: Zhang, Xiaotong, et al.
Publicado: (2023)

Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis
por: Kajal, Kirti, et al.
Publicado: (2019)

Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation
por: Volná, Adriana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pcngfej6rblb9jb934c4bt2dsg