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In Situ Quenching of Trialkylphosphine Reducing Agents Using Water-Soluble PEG-Azides Improves Maleimide Conjugation to Proteins

[Image: see text] Trialkylphosphines tris(2-carboxy-ethyl)-phosphine and tris(3-hydroxypropyl)-phosphine are popular reagents for the reduction of cysteine residues in bioconjugation reactions using maleimides. However, it has been demonstrated that these phosphines are reactive toward maleimide, ne...

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Detalles Bibliográficos
Autores principales:	Kantner, Terrence, Alkhawaja, Bayan, Watts, Andrew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044941/ https://www.ncbi.nlm.nih.gov/pubmed/30023752 http://dx.doi.org/10.1021/acsomega.7b01094

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