Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene

[Image: see text] Water-soluble pillar[6]arene (WP6) was used to solubilize camptothecin family antitumor drugs. In the presence of WP6, the solubility of camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) was enhanced by 380 and 40 times, respectively. The solubility enhancement is proved to be t...

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Autores principales: Liu, Yamin, Chen, Xi, Ding, Jiaming, Yu, Lin, Ma, Da, Ding, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044948/
https://www.ncbi.nlm.nih.gov/pubmed/30023745
http://dx.doi.org/10.1021/acsomega.7b01032
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author Liu, Yamin
Chen, Xi
Ding, Jiaming
Yu, Lin
Ma, Da
Ding, Jiandong
author_facet Liu, Yamin
Chen, Xi
Ding, Jiaming
Yu, Lin
Ma, Da
Ding, Jiandong
author_sort Liu, Yamin
collection PubMed
description [Image: see text] Water-soluble pillar[6]arene (WP6) was used to solubilize camptothecin family antitumor drugs. In the presence of WP6, the solubility of camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) was enhanced by 380 and 40 times, respectively. The solubility enhancement is proved to be the result of the host–guest encapsulation by WP6. WP6 has a low cytotoxicity against normal MC 3T3-E1 cells, whereas the bioactivity of CPT and HCPT is substantially improved as a result of the solubility enhancement.
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spelling pubmed-60449482018-07-16 Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene Liu, Yamin Chen, Xi Ding, Jiaming Yu, Lin Ma, Da Ding, Jiandong ACS Omega [Image: see text] Water-soluble pillar[6]arene (WP6) was used to solubilize camptothecin family antitumor drugs. In the presence of WP6, the solubility of camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) was enhanced by 380 and 40 times, respectively. The solubility enhancement is proved to be the result of the host–guest encapsulation by WP6. WP6 has a low cytotoxicity against normal MC 3T3-E1 cells, whereas the bioactivity of CPT and HCPT is substantially improved as a result of the solubility enhancement. American Chemical Society 2017-08-31 /pmc/articles/PMC6044948/ /pubmed/30023745 http://dx.doi.org/10.1021/acsomega.7b01032 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liu, Yamin
Chen, Xi
Ding, Jiaming
Yu, Lin
Ma, Da
Ding, Jiandong
Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title_full Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title_fullStr Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title_full_unstemmed Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title_short Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
title_sort improved solubility and bioactivity of camptothecin family antitumor drugs with supramolecular encapsulation by water-soluble pillar[6]arene
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044948/
https://www.ncbi.nlm.nih.gov/pubmed/30023745
http://dx.doi.org/10.1021/acsomega.7b01032
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