Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles

[Image: see text] Multidrug-resistant Staphylococcus aureus (MRSA) has become one of the major causes of various infections, leading to morbidity in both healthy and immune-compromised populations worldwide. Herein, we report a novel type of hybrid photosensitizer based on amphiphilic block copolyme...

Descripción completa

Detalles Bibliográficos
Autores principales: Wijesiri, Niranga, Ozkaya-Ahmadov, Tevhide, Wang, Peng, Zhang, Jinnan, Tang, Hong, Yu, Xinjun, Ayres, Neil, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044965/
https://www.ncbi.nlm.nih.gov/pubmed/30023747
http://dx.doi.org/10.1021/acsomega.7b00738
_version_ 1783339583516180480
author Wijesiri, Niranga
Ozkaya-Ahmadov, Tevhide
Wang, Peng
Zhang, Jinnan
Tang, Hong
Yu, Xinjun
Ayres, Neil
Zhang, Peng
author_facet Wijesiri, Niranga
Ozkaya-Ahmadov, Tevhide
Wang, Peng
Zhang, Jinnan
Tang, Hong
Yu, Xinjun
Ayres, Neil
Zhang, Peng
author_sort Wijesiri, Niranga
collection PubMed
description [Image: see text] Multidrug-resistant Staphylococcus aureus (MRSA) has become one of the major causes of various infections, leading to morbidity in both healthy and immune-compromised populations worldwide. Herein, we report a novel type of hybrid photosensitizer based on amphiphilic block copolymer-functionalized gold nanoparticles. The design of the nanoparticles provides a facile means to incorporate hydrophobic photosensitizing molecules for use in aqueous media. The hybrid photosensitizers display greatly enhanced singlet oxygen generation and outstanding photodynamic inactivation (PDI) efficacy against MRSA under light illumination. These hybrid photosensitizers greatly improve the effectiveness of PDI against MRSA while not involving antibiotics.
format Online
Article
Text
id pubmed-6044965
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-60449652018-07-16 Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles Wijesiri, Niranga Ozkaya-Ahmadov, Tevhide Wang, Peng Zhang, Jinnan Tang, Hong Yu, Xinjun Ayres, Neil Zhang, Peng ACS Omega [Image: see text] Multidrug-resistant Staphylococcus aureus (MRSA) has become one of the major causes of various infections, leading to morbidity in both healthy and immune-compromised populations worldwide. Herein, we report a novel type of hybrid photosensitizer based on amphiphilic block copolymer-functionalized gold nanoparticles. The design of the nanoparticles provides a facile means to incorporate hydrophobic photosensitizing molecules for use in aqueous media. The hybrid photosensitizers display greatly enhanced singlet oxygen generation and outstanding photodynamic inactivation (PDI) efficacy against MRSA under light illumination. These hybrid photosensitizers greatly improve the effectiveness of PDI against MRSA while not involving antibiotics. American Chemical Society 2017-09-01 /pmc/articles/PMC6044965/ /pubmed/30023747 http://dx.doi.org/10.1021/acsomega.7b00738 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Wijesiri, Niranga
Ozkaya-Ahmadov, Tevhide
Wang, Peng
Zhang, Jinnan
Tang, Hong
Yu, Xinjun
Ayres, Neil
Zhang, Peng
Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title_full Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title_fullStr Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title_full_unstemmed Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title_short Photodynamic Inactivation of Multidrug-Resistant Staphylococcus aureus Using Hybrid Photosensitizers Based on Amphiphilic Block Copolymer-Functionalized Gold Nanoparticles
title_sort photodynamic inactivation of multidrug-resistant staphylococcus aureus using hybrid photosensitizers based on amphiphilic block copolymer-functionalized gold nanoparticles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044965/
https://www.ncbi.nlm.nih.gov/pubmed/30023747
http://dx.doi.org/10.1021/acsomega.7b00738
work_keys_str_mv AT wijesiriniranga photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT ozkayaahmadovtevhide photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT wangpeng photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT zhangjinnan photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT tanghong photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT yuxinjun photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT ayresneil photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles
AT zhangpeng photodynamicinactivationofmultidrugresistantstaphylococcusaureususinghybridphotosensitizersbasedonamphiphilicblockcopolymerfunctionalizedgoldnanoparticles

Ejemplares similares