Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae

[Image: see text] Ophiosphaerellins A–I (1–9), the first example of bicyclo[4.1.0]heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A–B (10–11) were isolated from the endolichenic fungus Ophiosphaerella korrae. Biosynthetically, they were derived from the polyketide pathway, an...

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Autores principales: Li, Yuelan, Zhu, Rongxiu, Zhang, Jiaozhen, Xie, Fei, Wang, Xiaoning, Xu, Ke, Qiao, Yanan, Zhao, Zuntian, Lou, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045351/
https://www.ncbi.nlm.nih.gov/pubmed/30023771
http://dx.doi.org/10.1021/acsomega.7b01668
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author Li, Yuelan
Zhu, Rongxiu
Zhang, Jiaozhen
Xie, Fei
Wang, Xiaoning
Xu, Ke
Qiao, Yanan
Zhao, Zuntian
Lou, Hongxiang
author_facet Li, Yuelan
Zhu, Rongxiu
Zhang, Jiaozhen
Xie, Fei
Wang, Xiaoning
Xu, Ke
Qiao, Yanan
Zhao, Zuntian
Lou, Hongxiang
author_sort Li, Yuelan
collection PubMed
description [Image: see text] Ophiosphaerellins A–I (1–9), the first example of bicyclo[4.1.0]heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A–B (10–11) were isolated from the endolichenic fungus Ophiosphaerella korrae. Biosynthetically, they were derived from the polyketide pathway, and their absolute configurations were determined on the basis of the combination analysis of spectral data, circular dichroism calculations, and single-crystal X-ray diffraction measurement. Preliminary test with thin-layer chromatography bioautography found that this type of compounds showed moderate acetylcholinesterase (AChE) inhibitory effects.
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spelling pubmed-60453512018-07-16 Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae Li, Yuelan Zhu, Rongxiu Zhang, Jiaozhen Xie, Fei Wang, Xiaoning Xu, Ke Qiao, Yanan Zhao, Zuntian Lou, Hongxiang ACS Omega [Image: see text] Ophiosphaerellins A–I (1–9), the first example of bicyclo[4.1.0]heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A–B (10–11) were isolated from the endolichenic fungus Ophiosphaerella korrae. Biosynthetically, they were derived from the polyketide pathway, and their absolute configurations were determined on the basis of the combination analysis of spectral data, circular dichroism calculations, and single-crystal X-ray diffraction measurement. Preliminary test with thin-layer chromatography bioautography found that this type of compounds showed moderate acetylcholinesterase (AChE) inhibitory effects. American Chemical Society 2018-01-05 /pmc/articles/PMC6045351/ /pubmed/30023771 http://dx.doi.org/10.1021/acsomega.7b01668 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Li, Yuelan
Zhu, Rongxiu
Zhang, Jiaozhen
Xie, Fei
Wang, Xiaoning
Xu, Ke
Qiao, Yanan
Zhao, Zuntian
Lou, Hongxiang
Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title_full Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title_fullStr Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title_full_unstemmed Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title_short Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae
title_sort ophiosphaerellins a–i, polyketide-derived compounds from the endolichenic fungus ophiosphaerella korrae
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045351/
https://www.ncbi.nlm.nih.gov/pubmed/30023771
http://dx.doi.org/10.1021/acsomega.7b01668
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