Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases
[Image: see text] Overexpression of the eukaryotic initiation factor 4E (eIF4E) is linked to a variety of cancers. Both mitogen-activated protein kinases-interacting kinases 1 and 2 (Mnk1/2) activate the oncogene eIF4E through posttranslational modification (phosphorylating it at the conserved Ser20...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045392/ https://www.ncbi.nlm.nih.gov/pubmed/30023565 http://dx.doi.org/10.1021/acsomega.7b01403 |