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Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases

[Image: see text] Overexpression of the eukaryotic initiation factor 4E (eIF4E) is linked to a variety of cancers. Both mitogen-activated protein kinases-interacting kinases 1 and 2 (Mnk1/2) activate the oncogene eIF4E through posttranslational modification (phosphorylating it at the conserved Ser20...

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Detalles Bibliográficos
Autores principales:	Kannan, Srinivasaraghavan, Pradhan, Mohan R., Cherian, Joseph, Joseph, Thomas L., Poh, Zhi Ying, Hai Yan, Yang, Melvyn, Ho, Boping, Liu, Jeffrey, Hill, Nacro, Kassoum, Verma, Chandra S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045392/ https://www.ncbi.nlm.nih.gov/pubmed/30023565 http://dx.doi.org/10.1021/acsomega.7b01403

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