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Ultrafine Highly Magnetic Fluorescent γ-Fe(2)O(3)/NCD Nanocomposites for Neuronal Manipulations

[Image: see text] In this work, we describe a low-cost, two-step synthesis of composites of nitrogen-doped carbon quantum dots (NCDs) with γ-Fe(2)O(3) (NCDs/γ-Fe(2)O(3)), which is based on a hydrothermal cum co-precipitation method. The product is a fine powder of particles having an average diamete...

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Detalles Bibliográficos
Autores principales: Kumar, Vijay Bhooshan, Marcus, Michal, Porat, Ze’ev, Shani, Lior, Yeshurun, Yosef, Felner, Israel, Shefi, Orit, Gedanken, Aharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045473/
https://www.ncbi.nlm.nih.gov/pubmed/30023817
http://dx.doi.org/10.1021/acsomega.7b01666
Descripción
Sumario:[Image: see text] In this work, we describe a low-cost, two-step synthesis of composites of nitrogen-doped carbon quantum dots (NCDs) with γ-Fe(2)O(3) (NCDs/γ-Fe(2)O(3)), which is based on a hydrothermal cum co-precipitation method. The product is a fine powder of particles having an average diameter of 9 ± 3 nm. The physical and chemical properties of NCDs/γ-Fe(2)O(3) were studied, as well as the superconducting quantum interference device and Mossbauer analysis of the magnetic properties of these nanocomposites. The interaction of NCDs/γ-Fe(2)O(3) nanocomposites with neuron-like cells was examined, showing efficient uptake and low toxicity. Our research demonstrates the use of the nanocomposites for imaging and for controlling the cellular motility. The NCDs/γ-Fe(2)O(3) nanocomposites are promising because of their biocompatibility, photostability, and potential selective affinity, paving the way for multifunctional biomedical applications.