Cargando…

Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6

[Image: see text] The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp(NMe)K) was decorated with different chelators (DOTPI, DOTAGA, and DOTA). The Lu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Färber, Stefanie Felicitas, Wurzer, Alexander, Reichart, Florian, Beck, Roswitha, Kessler, Horst, Wester, Hans-Jürgen, Notni, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045477/ https://www.ncbi.nlm.nih.gov/pubmed/30023833 http://dx.doi.org/10.1021/acsomega.8b00035

Ejemplares similares

Dual‐Nuclide Radiopharmaceuticals for Positron Emission Tomography Based Dosimetry in Radiotherapy
por: Wurzer, Alexander, et al.
Publicado: (2017)

Exploring the Role of RGD-Recognizing Integrins in Cancer
por: Nieberler, Markus, et al.
Publicado: (2017)

It’s Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals
por: Kossatz, Susanne, et al.
Publicado: (2021)

Comparison of cyclic RGD peptides for α(v)β(3) integrin detection in a rat model of myocardial infarction
por: Laitinen, Iina, et al.
Publicado: (2013)

PET Imaging of Integrin αVβ3 Expression
por: Beer, Ambros J., et al.
Publicado: (2011)

Perspective of α(v)β(6)-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions
por: Steiger, Katja, et al.
Publicado: (2017)

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
por: Kapp, Tobias G., et al.
Publicado: (2017)

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

Preclinical comparison of four [(18)F, (nat)Ga]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics
por: Wurzer, Alexander, et al.
Publicado: (2020)

Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry
por: Wurzer, Alexander, et al.
Publicado: (2018)

PET/CT imaging of pancreatic carcinoma targeting the “cancer integrin” αvβ6
por: Quigley, Neil Gerard, et al.
Publicado: (2021)

Effect of Carbohydration on the Theranostic Tracer PSMA I&T
por: Schmidt, Alexander, et al.
Publicado: (2018)

Palmitic Acid-Conjugated Radiopharmaceutical for Integrin α(v)β(3)-Targeted Radionuclide Therapy
por: Yang, Guangjie, et al.
Publicado: (2022)

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
por: Steiger, Katja, et al.
Publicado: (2021)

Radiohybrid Ligands: A Novel Tracer Concept Exemplified by (18)F- or (68)Ga-Labeled rhPSMA Inhibitors
por: Wurzer, Alexander, et al.
Publicado: (2020)

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α(v)β(3)- or α(5)β(1)-Integrins
por: Rahmouni, Sabri, et al.
Publicado: (2013)

Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling
por: Vágner, Adrienn, et al.
Publicado: (2018)

Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin
por: Missirlis, Dimitris, et al.
Publicado: (2016)

Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand
por: Tomassi, Stefano, et al.
Publicado: (2021)

Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
por: Schottelius, Margret, et al.
Publicado: (2019)

Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [(18)F]Galacto-RGD
por: Haubner, Roland, et al.
Publicado: (2005)

Bone-seeking TRAP conjugates: surprising observations and their implications on the development of gallium-68-labeled bisphosphonates
por: Notni, Johannes, et al.
Publicado: (2012)

Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET
por: Notni, Johannes, et al.
Publicado: (2012)

First‐Generation Bispidine Chelators for (213)Bi(III) Radiopharmaceutical Applications
por: Bruchertseifer, Frank, et al.
Publicado: (2020)

Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells
por: Young, Jennifer L., et al.
Publicado: (2020)

Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow
por: Makowski, Marcus R., et al.
Publicado: (2020)

Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly
por: Schaufler, Viktoria, et al.
Publicado: (2016)

Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics
por: Šimeček, Jakub, et al.
Publicado: (2018)

Substitution of l-Tryptophan by α-Methyl-l-Tryptophan in (177)Lu-RM2 Results in (177)Lu-AMTG, a High-Affinity Gastrin-Releasing Peptide Receptor Ligand with Improved In Vivo Stability
por: Günther, Thomas, et al.
Publicado: (2022)

Synthesis and Preclinical Evaluation of (177)Lu-Labeled Radiohybrid PSMA Ligands for Endoradiotherapy of Prostate Cancer
por: Wurzer, Alexander, et al.
Publicado: (2022)

Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
por: Quigley, Neil Gerard, et al.
Publicado: (2020)

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin
por: Sani, Saidu, et al.
Publicado: (2022)

Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α(5)β(1) integrin towards choleresis
por: Bonus, Michele, et al.
Publicado: (2020)

PET Radiopharmaceuticals for Imaging Integrin Expression: Tracers in Clinical Studies and Recent Developments
por: Haubner, Roland, et al.
Publicado: (2014)

Integrins α(v)β(3) and α(v)β(5) as prognostic, diagnostic, and therapeutic targets in gastric cancer
por: Böger, Christine, et al.
Publicado: (2014)

Dosing Therapeutic Radiopharmaceuticals in Obese Patients
por: van Nuland, Merel, et al.
Publicado: (2022)

Non-invasive assessment of inter-and intrapatient variability of integrin expression in metastasized prostate cancer by PET
por: Beer, Ambros J., et al.
Publicado: (2016)

Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
por: Di Russo, Jacopo, et al.
Publicado: (2021)

PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin
por: Quigley, Neil Gerard, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qenier5qo9f510sf3i3evhrubl