Total Synthesis of Desmethyl Jahanyne and Its Lipo-Tetrapeptide Conjugates Derived from Parent Skeleton as BCL-2-Mediated Apoptosis-Inducing Agents

[Image: see text] The total synthesis of highly potent and scarcely available marine natural product (−)-jahanyne was attempted resulting in a solution-phase synthesis of pruned versions with comparable activity. A simple and facile synthetic route was employed for the preparation of pruned congener...

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Detalles Bibliográficos
Autores principales: Kallepu, Shivakrishna, Kavitha, Minnapuram, Yeeravalli, Ragini, Manupati, Kanakaraju, Jadav, Surender Singh, Das, Amitava, Mainkar, Prathama S., Chandrasekhar, Srivari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045489/
https://www.ncbi.nlm.nih.gov/pubmed/30023766
http://dx.doi.org/10.1021/acsomega.7b01634

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