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Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endang...

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Detalles Bibliográficos
Autores principales:	Smedley, Christopher J., Stanley, Paul A., Qazzaz, Mohannad E., Prota, Andrea E., Olieric, Natacha, Collins, Hilary, Eastman, Harry, Barrow, Andrew S., Lim, Kuan-Hon, Kam, Toh-Seok, Smith, Brian J., Duivenvoorden, Hendrika M., Parker, Belinda S., Bradshaw, Tracey D., Steinmetz, Michel O., Moses, John E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045569/ https://www.ncbi.nlm.nih.gov/pubmed/30006510 http://dx.doi.org/10.1038/s41598-018-28880-2

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