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Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)

Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 pl...

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Autores principales: Lamichhane, Santosh, Ahonen, Linda, Dyrlund, Thomas Sparholt, Kemppainen, Esko, Siljander, Heli, Hyöty, Heikki, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyötyläinen, Tuulia, Knip, Mikael, Oresic, Matej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045612/
https://www.ncbi.nlm.nih.gov/pubmed/30006587
http://dx.doi.org/10.1038/s41598-018-28907-8
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author Lamichhane, Santosh
Ahonen, Linda
Dyrlund, Thomas Sparholt
Kemppainen, Esko
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
author_facet Lamichhane, Santosh
Ahonen, Linda
Dyrlund, Thomas Sparholt
Kemppainen, Esko
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
author_sort Lamichhane, Santosh
collection PubMed
description Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.
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spelling pubmed-60456122018-07-16 Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP) Lamichhane, Santosh Ahonen, Linda Dyrlund, Thomas Sparholt Kemppainen, Esko Siljander, Heli Hyöty, Heikki Ilonen, Jorma Toppari, Jorma Veijola, Riitta Hyötyläinen, Tuulia Knip, Mikael Oresic, Matej Sci Rep Article Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity. Nature Publishing Group UK 2018-07-13 /pmc/articles/PMC6045612/ /pubmed/30006587 http://dx.doi.org/10.1038/s41598-018-28907-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lamichhane, Santosh
Ahonen, Linda
Dyrlund, Thomas Sparholt
Kemppainen, Esko
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title_full Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title_fullStr Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title_full_unstemmed Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title_short Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
title_sort dynamics of plasma lipidome in progression to islet autoimmunity and type 1 diabetes – type 1 diabetes prediction and prevention study (dipp)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045612/
https://www.ncbi.nlm.nih.gov/pubmed/30006587
http://dx.doi.org/10.1038/s41598-018-28907-8
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