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Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Using a novel RNA replicon-based vaccine, we show the impact of PMIF immunoneutralization on the host response and observed improved control...

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Detalles Bibliográficos
Autores principales:	Baeza Garcia, Alvaro, Siu, Edwin, Sun, Tiffany, Exler, Valerie, Brito, Luis, Hekele, Armin, Otten, Gib, Augustijn, Kevin, Janse, Chris J., Ulmer, Jeffrey B., Bernhagen, Jürgen, Fikrig, Erol, Geall, Andrew, Bucala, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045615/ https://www.ncbi.nlm.nih.gov/pubmed/30006528 http://dx.doi.org/10.1038/s41467-018-05041-7

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