Cargando…
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103(+)CD39(+) tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both in primary and metastatic tumors. This CD8...
Autores principales: | Duhen, Thomas, Duhen, Rebekka, Montler, Ryan, Moses, Jake, Moudgil, Tarsem, de Miranda, Noel F., Goodall, Cheri P., Blair, Tiffany C., Fox, Bernard A., McDermott, Jason E., Chang, Shu-Ching, Grunkemeier, Gary, Leidner, Rom, Bell, Richard Bryan, Weinberg, Andrew D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045647/ https://www.ncbi.nlm.nih.gov/pubmed/30006565 http://dx.doi.org/10.1038/s41467-018-05072-0 |
Ejemplares similares
-
CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden
por: van den Bulk, Jitske, et al.
Publicado: (2023) -
Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help
por: Medler, Terry R., et al.
Publicado: (2023) -
PD-1 and ICOS coexpression identifies tumor-reactive CD4(+) T cells in human solid tumors
por: Duhen, Rebekka, et al.
Publicado: (2022) -
Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes
por: Duhen, Thomas, et al.
Publicado: (2022) -
Human naive and memory CD4(+) T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
por: Geiger, Rebekka, et al.
Publicado: (2009)