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Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045671/ https://www.ncbi.nlm.nih.gov/pubmed/30006603 http://dx.doi.org/10.1038/s41598-018-28928-3 |
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author | Poma, Anello Marcello Torregrossa, Liborio Bruno, Rossella Basolo, Fulvio Fontanini, Gabriella |
author_facet | Poma, Anello Marcello Torregrossa, Liborio Bruno, Rossella Basolo, Fulvio Fontanini, Gabriella |
author_sort | Poma, Anello Marcello |
collection | PubMed |
description | The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value. Survival analyses were performed to identify independent predictors, taking into account the main clinical-pathological features affecting OS. Finally, independent predictors were correlated with YAP1 oncoprotein expression. At least one of the Hippo genes is an independent prognostic factor in 12 out of 13 considered tumor datasets. mRNA levels of the independent predictors coherently correlate with YAP1 in glioma, kidney renal clear cell, head and neck, and bladder cancer. Moreover, literature data revealed the association between YAP1 levels and OS in gastric, colorectal, hepatocellular, pancreatic, and lung cancer. Herein, we identified cancers in which Hippo pathway affects OS; these cancers should be candidates for YAP1 inhibitors development and testing. |
format | Online Article Text |
id | pubmed-6045671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60456712018-07-16 Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature Poma, Anello Marcello Torregrossa, Liborio Bruno, Rossella Basolo, Fulvio Fontanini, Gabriella Sci Rep Article The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value. Survival analyses were performed to identify independent predictors, taking into account the main clinical-pathological features affecting OS. Finally, independent predictors were correlated with YAP1 oncoprotein expression. At least one of the Hippo genes is an independent prognostic factor in 12 out of 13 considered tumor datasets. mRNA levels of the independent predictors coherently correlate with YAP1 in glioma, kidney renal clear cell, head and neck, and bladder cancer. Moreover, literature data revealed the association between YAP1 levels and OS in gastric, colorectal, hepatocellular, pancreatic, and lung cancer. Herein, we identified cancers in which Hippo pathway affects OS; these cancers should be candidates for YAP1 inhibitors development and testing. Nature Publishing Group UK 2018-07-13 /pmc/articles/PMC6045671/ /pubmed/30006603 http://dx.doi.org/10.1038/s41598-018-28928-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Poma, Anello Marcello Torregrossa, Liborio Bruno, Rossella Basolo, Fulvio Fontanini, Gabriella Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title | Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title_full | Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title_fullStr | Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title_full_unstemmed | Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title_short | Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature |
title_sort | hippo pathway affects survival of cancer patients: extensive analysis of tcga data and review of literature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045671/ https://www.ncbi.nlm.nih.gov/pubmed/30006603 http://dx.doi.org/10.1038/s41598-018-28928-3 |
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