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Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study

INTRODUCTION: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Recent findings suggest that AF is also associated with out-of-hospital cardiac arrest. However, whether that association can be generalised to in-hospital cardiac arrests (IHCAs) is still unknown. AIMS: To...

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Autores principales: Ryden, Alexander, Engdahl, Johan, Claesson, Andreas, Nordberg, Per, Ringh, Mattias, Hollenberg, Jacob, Djärv, Therese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045753/
https://www.ncbi.nlm.nih.gov/pubmed/29961035
http://dx.doi.org/10.1136/bmjopen-2018-022092
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author Ryden, Alexander
Engdahl, Johan
Claesson, Andreas
Nordberg, Per
Ringh, Mattias
Hollenberg, Jacob
Djärv, Therese
author_facet Ryden, Alexander
Engdahl, Johan
Claesson, Andreas
Nordberg, Per
Ringh, Mattias
Hollenberg, Jacob
Djärv, Therese
author_sort Ryden, Alexander
collection PubMed
description INTRODUCTION: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Recent findings suggest that AF is also associated with out-of-hospital cardiac arrest. However, whether that association can be generalised to in-hospital cardiac arrests (IHCAs) is still unknown. AIMS: To examine whether there is a stronger association with IHCA among hospitalised patients with AF compared with patients without AF. MATERIALS AND METHODS: All adult patients admitted to the Karolinska University Hospital, Stockholm, Sweden during 2014–2015 were included. Data were drawn from their medical file and matched against the Swedish Registry for Cardiopulmonary Resuscitation. Patients who were documented as ever having the International Classification of Diseases, 10th revision code I48 prior to the current hospitalisation were categorised to the AF group and the remaining were categorised to the non-AF group. The primary outcome was occurrence of an IHCA. RESULTS: In all, 102 416 patients were included. Among these, 10% had been diagnosed with AF and <1% (n=326) suffered from an IHCA, only 42 (13%) had a VF/VT. In a multivariable model adjusting for sex, age, CharlsonComorbidity Index score and whether the patients had been admitted electively or urgently, having AF was significantly associated with IHCA (OR 1.760; 95% CI 1.356 to 2.269; p<0.001). CONCLUSIONS: Within this observational cohort study, patients with AF had a stronger association with IHCA than patients without AF. AF might be an independent risk factor for IHCA.
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spelling pubmed-60457532018-07-18 Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study Ryden, Alexander Engdahl, Johan Claesson, Andreas Nordberg, Per Ringh, Mattias Hollenberg, Jacob Djärv, Therese BMJ Open Epidemiology INTRODUCTION: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Recent findings suggest that AF is also associated with out-of-hospital cardiac arrest. However, whether that association can be generalised to in-hospital cardiac arrests (IHCAs) is still unknown. AIMS: To examine whether there is a stronger association with IHCA among hospitalised patients with AF compared with patients without AF. MATERIALS AND METHODS: All adult patients admitted to the Karolinska University Hospital, Stockholm, Sweden during 2014–2015 were included. Data were drawn from their medical file and matched against the Swedish Registry for Cardiopulmonary Resuscitation. Patients who were documented as ever having the International Classification of Diseases, 10th revision code I48 prior to the current hospitalisation were categorised to the AF group and the remaining were categorised to the non-AF group. The primary outcome was occurrence of an IHCA. RESULTS: In all, 102 416 patients were included. Among these, 10% had been diagnosed with AF and <1% (n=326) suffered from an IHCA, only 42 (13%) had a VF/VT. In a multivariable model adjusting for sex, age, CharlsonComorbidity Index score and whether the patients had been admitted electively or urgently, having AF was significantly associated with IHCA (OR 1.760; 95% CI 1.356 to 2.269; p<0.001). CONCLUSIONS: Within this observational cohort study, patients with AF had a stronger association with IHCA than patients without AF. AF might be an independent risk factor for IHCA. BMJ Publishing Group 2018-06-30 /pmc/articles/PMC6045753/ /pubmed/29961035 http://dx.doi.org/10.1136/bmjopen-2018-022092 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Ryden, Alexander
Engdahl, Johan
Claesson, Andreas
Nordberg, Per
Ringh, Mattias
Hollenberg, Jacob
Djärv, Therese
Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title_full Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title_fullStr Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title_full_unstemmed Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title_short Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study
title_sort is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a swedish retrospective cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045753/
https://www.ncbi.nlm.nih.gov/pubmed/29961035
http://dx.doi.org/10.1136/bmjopen-2018-022092
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