Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

Lysosome membrane recycling occurs at the end of the autophagic pathway and requires proteins that are mostly encoded by genes mutated in neurodegenerative diseases. However, its implication in neuronal death is still unclear. Here, we show that spatacsin, which is required for lysosome recycling an...

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Detalles Bibliográficos
Autores principales: Boutry, Maxime, Branchu, Julien, Lustremant, Céline, Pujol, Claire, Pernelle, Julie, Matusiak, Raphaël, Seyer, Alexandre, Poirel, Marion, Chu-Van, Emeline, Pierga, Alexandre, Dobrenis, Kostantin, Puech, Jean-Philippe, Caillaud, Catherine, Durr, Alexandra, Brice, Alexis, Colsch, Benoit, Mochel, Fanny, El Hachimi, Khalid Hamid, Stevanin, Giovanni, Darios, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045775/
https://www.ncbi.nlm.nih.gov/pubmed/29949766
http://dx.doi.org/10.1016/j.celrep.2018.05.098

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