Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples

BACKGROUND: HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events. METHODS: We interrogated the genomic structure of 18 clinically-defined HER2+ breast tumors through integrated analysis of whole genome and transcriptome sequencing, coupl...

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Detalles Bibliográficos
Autores principales: Vasmatzis, George, Wang, Xue, Smadbeck, James B., Murphy, Stephen J., Geiersbach, Katherine B., Johnson, Sarah H., Gaitatzes, Athanasios G., Asmann, Yan W., Kosari, Farhad, Borad, Mitesh J., Serie, Daniel J., McLaughlin, Sarah A., Kachergus, Jennifer M., Necela, Brian M., Aubrey Thompson, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045826/
https://www.ncbi.nlm.nih.gov/pubmed/30005627
http://dx.doi.org/10.1186/s12885-018-4594-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045826/
https://www.ncbi.nlm.nih.gov/pubmed/30005627
http://dx.doi.org/10.1186/s12885-018-4594-0

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