Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling

BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most challenging tasks for management. The current therapeutic regimens may select and enrich cancer stem-like cells (CSCs) resulting in the increased r...

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Detalles Bibliográficos
Autores principales: Cai, Mao-Hua, Xu, Xiao-Gang, Yan, Shi-Li, Sun, Ze, Ying, Yin, Wang, Bai-Kui, Tu, Yue-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045878/
https://www.ncbi.nlm.nih.gov/pubmed/30005681
http://dx.doi.org/10.1186/s13046-018-0836-x

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