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Prediction of Response to Treatment in Children with Epilepsy

OBJECTIVE: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs. MATERIAL AND METHODS: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The...

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Autores principales: GHOFRANI, Mohammad, NASEHI, Mohammad Mehdi, SAKET, Sasan, MOLLAMOHAMMADI, Mohsen, TAGHDIRI, Mohammad Mahdi, KARIMZADEH, Parvaneh, TONEKABONI, Seyed Hassan, JAVADZADEH, Mohsen, JAFARI, Narjes, ZAVEHZAD, Azadeh, HASANVAND AMOUZADEH, Masoud, BESHRAT, Mahsa, BABAEI, Meysam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045937/
https://www.ncbi.nlm.nih.gov/pubmed/30026773
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author GHOFRANI, Mohammad
NASEHI, Mohammad Mehdi
SAKET, Sasan
MOLLAMOHAMMADI, Mohsen
TAGHDIRI, Mohammad Mahdi
KARIMZADEH, Parvaneh
TONEKABONI, Seyed Hassan
JAVADZADEH, Mohsen
JAFARI, Narjes
ZAVEHZAD, Azadeh
HASANVAND AMOUZADEH, Masoud
BESHRAT, Mahsa
BABAEI, Meysam
author_facet GHOFRANI, Mohammad
NASEHI, Mohammad Mehdi
SAKET, Sasan
MOLLAMOHAMMADI, Mohsen
TAGHDIRI, Mohammad Mahdi
KARIMZADEH, Parvaneh
TONEKABONI, Seyed Hassan
JAVADZADEH, Mohsen
JAFARI, Narjes
ZAVEHZAD, Azadeh
HASANVAND AMOUZADEH, Masoud
BESHRAT, Mahsa
BABAEI, Meysam
author_sort GHOFRANI, Mohammad
collection PubMed
description OBJECTIVE: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs. MATERIAL AND METHODS: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Patients were followed up for 6 months and the response to their treatment was recorded. The good response to treatment was defined as the absence of seizure with two drugs during follow up. RESULTS: Seventy-two patients (56.3%) were boys. The age of the first seizure was under 2 yr old in 90 patients (70.3%). History of febrile convulsion, family history of epilepsy and history of asphyxia was found in 16 (12.5%), 41 (32%), and 27 (21.1%) patients, respectively. Seizure etiology was idiopathic in 90 patients (70.3%), and the number of seizures was 1-2 in 36 patients (28.1%). Overall, 57 patients (44.5%) had cerebral lesion according to CT scan or MRI, and EEG was abnormal in 101 patients (78.9%). In 6-month follow-up, 40 patients (31.3%) responded well to the treatment and 88 patients (68.8%) responded poorly to the treatment. History of asphyxia (OR = 6.82), neonatal jaundice (OR = 2.81) and abnormal EEG (OR = 0.19) were effective factors in response to treatment. CONCLUSION: Abnormal EEG is an effective factor in treatment response in the children studied.
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spelling pubmed-60459372018-10-01 Prediction of Response to Treatment in Children with Epilepsy GHOFRANI, Mohammad NASEHI, Mohammad Mehdi SAKET, Sasan MOLLAMOHAMMADI, Mohsen TAGHDIRI, Mohammad Mahdi KARIMZADEH, Parvaneh TONEKABONI, Seyed Hassan JAVADZADEH, Mohsen JAFARI, Narjes ZAVEHZAD, Azadeh HASANVAND AMOUZADEH, Masoud BESHRAT, Mahsa BABAEI, Meysam Iran J Child Neurol Original Article OBJECTIVE: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs. MATERIAL AND METHODS: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Patients were followed up for 6 months and the response to their treatment was recorded. The good response to treatment was defined as the absence of seizure with two drugs during follow up. RESULTS: Seventy-two patients (56.3%) were boys. The age of the first seizure was under 2 yr old in 90 patients (70.3%). History of febrile convulsion, family history of epilepsy and history of asphyxia was found in 16 (12.5%), 41 (32%), and 27 (21.1%) patients, respectively. Seizure etiology was idiopathic in 90 patients (70.3%), and the number of seizures was 1-2 in 36 patients (28.1%). Overall, 57 patients (44.5%) had cerebral lesion according to CT scan or MRI, and EEG was abnormal in 101 patients (78.9%). In 6-month follow-up, 40 patients (31.3%) responded well to the treatment and 88 patients (68.8%) responded poorly to the treatment. History of asphyxia (OR = 6.82), neonatal jaundice (OR = 2.81) and abnormal EEG (OR = 0.19) were effective factors in response to treatment. CONCLUSION: Abnormal EEG is an effective factor in treatment response in the children studied. Shahid Beheshti University of Medical Sciences 2018 /pmc/articles/PMC6045937/ /pubmed/30026773 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
GHOFRANI, Mohammad
NASEHI, Mohammad Mehdi
SAKET, Sasan
MOLLAMOHAMMADI, Mohsen
TAGHDIRI, Mohammad Mahdi
KARIMZADEH, Parvaneh
TONEKABONI, Seyed Hassan
JAVADZADEH, Mohsen
JAFARI, Narjes
ZAVEHZAD, Azadeh
HASANVAND AMOUZADEH, Masoud
BESHRAT, Mahsa
BABAEI, Meysam
Prediction of Response to Treatment in Children with Epilepsy
title Prediction of Response to Treatment in Children with Epilepsy
title_full Prediction of Response to Treatment in Children with Epilepsy
title_fullStr Prediction of Response to Treatment in Children with Epilepsy
title_full_unstemmed Prediction of Response to Treatment in Children with Epilepsy
title_short Prediction of Response to Treatment in Children with Epilepsy
title_sort prediction of response to treatment in children with epilepsy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045937/
https://www.ncbi.nlm.nih.gov/pubmed/30026773
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