Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies...

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Detalles Bibliográficos
Autores principales: Yuan, Yuze, Ran, Nan, Xiong, Lingxin, Wang, Guoqiang, Guan, Xuewa, Wang, Ziyan, Guo, Yingqiao, Pang, Zhiqiang, Fang, Keyong, Lu, Junying, Zhang, Chao, Zheng, Ruipeng, Zheng, Jingtong, Ma, Jie, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046139/
https://www.ncbi.nlm.nih.gov/pubmed/30050954
http://dx.doi.org/10.1155/2018/1943497
Descripción
Sumario:Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.

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