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Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study
OBJECTIVE: This study sought to explore the prognostic factors in a large retrospective cohort of patients with primary central nervous system lymphoma (PCNSL) from the Surveillance, Epidemiology, and End Results database. METHODS: There were 5903 patients with PCNSL who had complete clinical inform...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046161/ https://www.ncbi.nlm.nih.gov/pubmed/30050595 http://dx.doi.org/10.1155/2018/7860494 |
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author | Shan, Yudong Hu, Yilan |
author_facet | Shan, Yudong Hu, Yilan |
author_sort | Shan, Yudong |
collection | PubMed |
description | OBJECTIVE: This study sought to explore the prognostic factors in a large retrospective cohort of patients with primary central nervous system lymphoma (PCNSL) from the Surveillance, Epidemiology, and End Results database. METHODS: There were 5903 patients with PCNSL who had complete clinical information and were identified in the Surveillance, Epidemiology, and End Results program between 1973 and 2014. The epidemiology, therapeutic measures, and clinical characteristics were listed as descriptive statistics. They were grouped into 4 categories: immunocompetent individual with diffuse large B cell lymphoma (DLBCL), immunocompetent individual with non-DLBCL, immunocompromised individual with DLBCL, and immunocompromised individual with non-DLBCL based on different subtypes and immunological status. Survival analysis was conducted with Cox regression models. RESULTS: Different demographics and clinical characteristics were identified as independent factors in different groups. In survival analysis, for patients with DLBCL, chemotherapy involving treatments was associated with the most favorable survival. Received-only radiation could be considered as a primary treatment in immunocompetent patients with non-DLBCL. These differences were statistically significant (P < 0.05). CONCLUSION: PCNSL patients treated with appropriate chemotherapy treatments may receive stable tumor control. |
format | Online Article Text |
id | pubmed-6046161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60461612018-07-26 Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study Shan, Yudong Hu, Yilan Dis Markers Research Article OBJECTIVE: This study sought to explore the prognostic factors in a large retrospective cohort of patients with primary central nervous system lymphoma (PCNSL) from the Surveillance, Epidemiology, and End Results database. METHODS: There were 5903 patients with PCNSL who had complete clinical information and were identified in the Surveillance, Epidemiology, and End Results program between 1973 and 2014. The epidemiology, therapeutic measures, and clinical characteristics were listed as descriptive statistics. They were grouped into 4 categories: immunocompetent individual with diffuse large B cell lymphoma (DLBCL), immunocompetent individual with non-DLBCL, immunocompromised individual with DLBCL, and immunocompromised individual with non-DLBCL based on different subtypes and immunological status. Survival analysis was conducted with Cox regression models. RESULTS: Different demographics and clinical characteristics were identified as independent factors in different groups. In survival analysis, for patients with DLBCL, chemotherapy involving treatments was associated with the most favorable survival. Received-only radiation could be considered as a primary treatment in immunocompetent patients with non-DLBCL. These differences were statistically significant (P < 0.05). CONCLUSION: PCNSL patients treated with appropriate chemotherapy treatments may receive stable tumor control. Hindawi 2018-06-28 /pmc/articles/PMC6046161/ /pubmed/30050595 http://dx.doi.org/10.1155/2018/7860494 Text en Copyright © 2018 Yudong Shan and Yilan Hu. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shan, Yudong Hu, Yilan Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title | Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title_full | Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title_fullStr | Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title_full_unstemmed | Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title_short | Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study |
title_sort | prognostic factors and survival in primary central nervous system lymphoma: a population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046161/ https://www.ncbi.nlm.nih.gov/pubmed/30050595 http://dx.doi.org/10.1155/2018/7860494 |
work_keys_str_mv | AT shanyudong prognosticfactorsandsurvivalinprimarycentralnervoussystemlymphomaapopulationbasedstudy AT huyilan prognosticfactorsandsurvivalinprimarycentralnervoussystemlymphomaapopulationbasedstudy |