Loss of NAMPT in aging retinal pigment epithelium reduces NAD(+) availability and promotes cellular senescence

Retinal pigment epithelium (RPE) performs numerous functions critical to retinal health and visual function. RPE senescence is a hallmark of aging and degenerative retinal disease development. Here, we evaluated the temporal expression of key nicotinamide adenine dinucleotide (NAD(+))-biosynthetic g...

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Detalles Bibliográficos
Autores principales: Jadeja, Ravirajsinh N., Powell, Folami L., Jones, Malita A., Fuller, Jasmine, Joseph, Ethan, Thounaojam, Menaka C., Bartoli, Manuela, Martin, Pamela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046249/
https://www.ncbi.nlm.nih.gov/pubmed/29905535
http://dx.doi.org/10.18632/aging.101469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046249/
https://www.ncbi.nlm.nih.gov/pubmed/29905535
http://dx.doi.org/10.18632/aging.101469

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