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Advancements in Regenerative Strategies Through the Continuum of Burn Care
Burns are caused by several mechanisms including flame, scald, chemical, electrical, and ionizing and non-ionizing radiation. Approximately half a million burn cases are registered annually, of which 40 thousand patients are hospitalized and receive definitive treatment. Burn care is very resource i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046385/ https://www.ncbi.nlm.nih.gov/pubmed/30038569 http://dx.doi.org/10.3389/fphar.2018.00672 |
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author | Stone II, Randolph Natesan, Shanmugasundaram Kowalczewski, Christine J. Mangum, Lauren H. Clay, Nicholas E. Clohessy, Ryan M. Carlsson, Anders H. Tassin, David H. Chan, Rodney K. Rizzo, Julie A. Christy, Robert J. |
author_facet | Stone II, Randolph Natesan, Shanmugasundaram Kowalczewski, Christine J. Mangum, Lauren H. Clay, Nicholas E. Clohessy, Ryan M. Carlsson, Anders H. Tassin, David H. Chan, Rodney K. Rizzo, Julie A. Christy, Robert J. |
author_sort | Stone II, Randolph |
collection | PubMed |
description | Burns are caused by several mechanisms including flame, scald, chemical, electrical, and ionizing and non-ionizing radiation. Approximately half a million burn cases are registered annually, of which 40 thousand patients are hospitalized and receive definitive treatment. Burn care is very resource intensive as the treatment regimens and length of hospitalization are substantial. Burn wounds are classified based on depth as superficial (first degree), partial-thickness (second degree), or full-thickness (third degree), which determines the treatment necessary for successful healing. The goal of burn wound care is to fully restore the barrier function of the tissue as quickly as possible while minimizing infection, scarring, and contracture. The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries. This review will present the current standard of care (SOC) and provide information on various treatment options that have been tested pre-clinically or are currently in clinical trials. Due to the complexity of burn wound healing compared to other skin injuries, burn specific treatment regimens must be developed. Recently, tissue engineering and regenerative medicine strategies have been developed to improve skin regeneration that can restore normal skin physiology and limit adverse outcomes, such as infection, delayed re-epithelialization, and scarring. Our emphasis will be centered on how current clinical and pre-clinical research of pharmacological agents, biomaterials, and cellular-based therapies can be applied throughout the continuum of burn care by targeting the stages of wound healing: hemostasis, inflammation, cell proliferation, and matrix remodeling. |
format | Online Article Text |
id | pubmed-6046385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60463852018-07-23 Advancements in Regenerative Strategies Through the Continuum of Burn Care Stone II, Randolph Natesan, Shanmugasundaram Kowalczewski, Christine J. Mangum, Lauren H. Clay, Nicholas E. Clohessy, Ryan M. Carlsson, Anders H. Tassin, David H. Chan, Rodney K. Rizzo, Julie A. Christy, Robert J. Front Pharmacol Pharmacology Burns are caused by several mechanisms including flame, scald, chemical, electrical, and ionizing and non-ionizing radiation. Approximately half a million burn cases are registered annually, of which 40 thousand patients are hospitalized and receive definitive treatment. Burn care is very resource intensive as the treatment regimens and length of hospitalization are substantial. Burn wounds are classified based on depth as superficial (first degree), partial-thickness (second degree), or full-thickness (third degree), which determines the treatment necessary for successful healing. The goal of burn wound care is to fully restore the barrier function of the tissue as quickly as possible while minimizing infection, scarring, and contracture. The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries. This review will present the current standard of care (SOC) and provide information on various treatment options that have been tested pre-clinically or are currently in clinical trials. Due to the complexity of burn wound healing compared to other skin injuries, burn specific treatment regimens must be developed. Recently, tissue engineering and regenerative medicine strategies have been developed to improve skin regeneration that can restore normal skin physiology and limit adverse outcomes, such as infection, delayed re-epithelialization, and scarring. Our emphasis will be centered on how current clinical and pre-clinical research of pharmacological agents, biomaterials, and cellular-based therapies can be applied throughout the continuum of burn care by targeting the stages of wound healing: hemostasis, inflammation, cell proliferation, and matrix remodeling. Frontiers Media S.A. 2018-07-09 /pmc/articles/PMC6046385/ /pubmed/30038569 http://dx.doi.org/10.3389/fphar.2018.00672 Text en Copyright © 2018 Stone, Natesan, Kowalczewski, Mangum, Clay, Clohessy, Carlsson, Tassin, Chan, Rizzo and Christy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Stone II, Randolph Natesan, Shanmugasundaram Kowalczewski, Christine J. Mangum, Lauren H. Clay, Nicholas E. Clohessy, Ryan M. Carlsson, Anders H. Tassin, David H. Chan, Rodney K. Rizzo, Julie A. Christy, Robert J. Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title | Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title_full | Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title_fullStr | Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title_full_unstemmed | Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title_short | Advancements in Regenerative Strategies Through the Continuum of Burn Care |
title_sort | advancements in regenerative strategies through the continuum of burn care |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046385/ https://www.ncbi.nlm.nih.gov/pubmed/30038569 http://dx.doi.org/10.3389/fphar.2018.00672 |
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