Gain of Function for the SCN1A/hNa(v)1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine

The SCN1A gene encodes for the voltage-dependent Na(v)1.1 Na(+) channel, an isoform mainly expressed in GABAergic neurons that is the target of hundreds of epileptogenic mutations. More recently, it has been shown that the SCN1A gene is also the target of mutations responsible for familial hemiplegi...

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Detalles Bibliográficos
Autores principales: Dhifallah, Sandra, Lancaster, Eric, Merrill, Shana, Leroudier, Nathalie, Mantegazza, Massimo, Cestèle, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046441/
https://www.ncbi.nlm.nih.gov/pubmed/30038559
http://dx.doi.org/10.3389/fnmol.2018.00232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046441/
https://www.ncbi.nlm.nih.gov/pubmed/30038559
http://dx.doi.org/10.3389/fnmol.2018.00232

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