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Radiation Matters of the Heart: A Mini Review
Radiation Therapy (RT) has been critical in cancer treatment regimens to date. However, it has been shown that ionizing radiation is also associated with increased risk of damage to healthy tissues. At high radiation doses, varied effects including inactivation of cells in treated tissue and associa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046516/ https://www.ncbi.nlm.nih.gov/pubmed/30038908 http://dx.doi.org/10.3389/fcvm.2018.00083 |
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author | Menezes, Kareena M. Wang, Huichen Hada, Megumi Saganti, Premkumar B. |
author_facet | Menezes, Kareena M. Wang, Huichen Hada, Megumi Saganti, Premkumar B. |
author_sort | Menezes, Kareena M. |
collection | PubMed |
description | Radiation Therapy (RT) has been critical in cancer treatment regimens to date. However, it has been shown that ionizing radiation is also associated with increased risk of damage to healthy tissues. At high radiation doses, varied effects including inactivation of cells in treated tissue and associated functional impairment are seen. These range from direct damage to the heart; particularly, diffuse fibrosis of the pericardium and myocardium, adhesion of the pericardium, injury to the blood vessels and stenosis. Cardiac damage is mostly a late responding end-point, occurring anywhere between 1 and 10 years after radiation procedures. Cardiovascular disease following radiotherapy was more common with radiation treatments used before the late 1980s. Modern RT regimens with more focused radiation beams, allow tumors to be targeted more precisely and shield the heart and other healthy tissues for minimizing the radiation damage to normal cells. In this review, we discuss radiation therapeutic doses used and post-radiation damage to the heart muscle from published studies. We also emphasize the need for early detection of cardiotoxicity and the need for more cardio-protection approaches where feasible. |
format | Online Article Text |
id | pubmed-6046516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60465162018-07-23 Radiation Matters of the Heart: A Mini Review Menezes, Kareena M. Wang, Huichen Hada, Megumi Saganti, Premkumar B. Front Cardiovasc Med Cardiovascular Medicine Radiation Therapy (RT) has been critical in cancer treatment regimens to date. However, it has been shown that ionizing radiation is also associated with increased risk of damage to healthy tissues. At high radiation doses, varied effects including inactivation of cells in treated tissue and associated functional impairment are seen. These range from direct damage to the heart; particularly, diffuse fibrosis of the pericardium and myocardium, adhesion of the pericardium, injury to the blood vessels and stenosis. Cardiac damage is mostly a late responding end-point, occurring anywhere between 1 and 10 years after radiation procedures. Cardiovascular disease following radiotherapy was more common with radiation treatments used before the late 1980s. Modern RT regimens with more focused radiation beams, allow tumors to be targeted more precisely and shield the heart and other healthy tissues for minimizing the radiation damage to normal cells. In this review, we discuss radiation therapeutic doses used and post-radiation damage to the heart muscle from published studies. We also emphasize the need for early detection of cardiotoxicity and the need for more cardio-protection approaches where feasible. Frontiers Media S.A. 2018-07-09 /pmc/articles/PMC6046516/ /pubmed/30038908 http://dx.doi.org/10.3389/fcvm.2018.00083 Text en Copyright © 2018 Menezes, Wang, Hada and Saganti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Menezes, Kareena M. Wang, Huichen Hada, Megumi Saganti, Premkumar B. Radiation Matters of the Heart: A Mini Review |
title | Radiation Matters of the Heart: A Mini Review |
title_full | Radiation Matters of the Heart: A Mini Review |
title_fullStr | Radiation Matters of the Heart: A Mini Review |
title_full_unstemmed | Radiation Matters of the Heart: A Mini Review |
title_short | Radiation Matters of the Heart: A Mini Review |
title_sort | radiation matters of the heart: a mini review |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046516/ https://www.ncbi.nlm.nih.gov/pubmed/30038908 http://dx.doi.org/10.3389/fcvm.2018.00083 |
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