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Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor

T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials. The anti-CD3ε antibody UCHT1 enhanced the in vitro tumor killing activity of human γδ T cell...

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Detalles Bibliográficos
Autores principales:	Juraske, Claudia, Wipa, Piyamaporn, Morath, Anna, Hidalgo, Jose Villacorta, Hartl, Frederike A., Raute, Katrin, Oberg, Hans-Heinrich, Wesch, Daniela, Fisch, Paul, Minguet, Susana, Pongcharoen, Sutatip, Schamel, Wolfgang W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046647/ https://www.ncbi.nlm.nih.gov/pubmed/30038626 http://dx.doi.org/10.3389/fimmu.2018.01579

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