Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae

INTRODUCTION: Increased incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported worldwide. The WHO warns about the imminent risk to global health if the spread of resistant bacteria is not contained. MATERIALS AND METHODS: Here, single molecule real time sequencing was used to a...

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Autor principal: Alfaresi, Mubarak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047195/
https://www.ncbi.nlm.nih.gov/pubmed/30069258
http://dx.doi.org/10.2174/1874285801812010195
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author Alfaresi, Mubarak
author_facet Alfaresi, Mubarak
author_sort Alfaresi, Mubarak
collection PubMed
description INTRODUCTION: Increased incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported worldwide. The WHO warns about the imminent risk to global health if the spread of resistant bacteria is not contained. MATERIALS AND METHODS: Here, single molecule real time sequencing was used to analyse the whole genome and resistome of SKGH01, a strain of Klebsiella pneumoniae. RESULTS AND DISCUSSIONS: The data showed that SKGH01 was resistant to all commercially available antibiotics. A complete account of extensively drug-resistant (XDR) CRE at a genomic level and the entire location map of all antibiotic resistance components are here presented. Additionally, this work proposes a model of XDR acquisition in Enterobacteriaceae.
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spelling pubmed-60471952018-08-01 Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae Alfaresi, Mubarak Open Microbiol J Microbiology INTRODUCTION: Increased incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported worldwide. The WHO warns about the imminent risk to global health if the spread of resistant bacteria is not contained. MATERIALS AND METHODS: Here, single molecule real time sequencing was used to analyse the whole genome and resistome of SKGH01, a strain of Klebsiella pneumoniae. RESULTS AND DISCUSSIONS: The data showed that SKGH01 was resistant to all commercially available antibiotics. A complete account of extensively drug-resistant (XDR) CRE at a genomic level and the entire location map of all antibiotic resistance components are here presented. Additionally, this work proposes a model of XDR acquisition in Enterobacteriaceae. Bentham Open 2018-06-29 /pmc/articles/PMC6047195/ /pubmed/30069258 http://dx.doi.org/10.2174/1874285801812010195 Text en © 2018 Mubarak Alfaresi. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Microbiology
Alfaresi, Mubarak
Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title_full Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title_fullStr Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title_full_unstemmed Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title_short Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
title_sort whole genome sequencing of klebsiella pneumoniae strain unravels a new model for the development of extensive drug resistance in enterobacteriaceae
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047195/
https://www.ncbi.nlm.nih.gov/pubmed/30069258
http://dx.doi.org/10.2174/1874285801812010195
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