Endothelial progenitor cells in age-related vascular remodeling

Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved...

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Detalles Bibliográficos
Autores principales: Yang, Jin-Xiu, Pan, Yan-Yun, Wang, Xing-Xiang, Qiu, Yuan-Gang, Mao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047273/
https://www.ncbi.nlm.nih.gov/pubmed/29882417
http://dx.doi.org/10.1177/0963689718779345
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author Yang, Jin-Xiu
Pan, Yan-Yun
Wang, Xing-Xiang
Qiu, Yuan-Gang
Mao, Wei
author_facet Yang, Jin-Xiu
Pan, Yan-Yun
Wang, Xing-Xiang
Qiu, Yuan-Gang
Mao, Wei
author_sort Yang, Jin-Xiu
collection PubMed
description Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed.
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spelling pubmed-60472732018-07-18 Endothelial progenitor cells in age-related vascular remodeling Yang, Jin-Xiu Pan, Yan-Yun Wang, Xing-Xiang Qiu, Yuan-Gang Mao, Wei Cell Transplant Reviews Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed. SAGE Publications 2018-06-08 2018-05 /pmc/articles/PMC6047273/ /pubmed/29882417 http://dx.doi.org/10.1177/0963689718779345 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Yang, Jin-Xiu
Pan, Yan-Yun
Wang, Xing-Xiang
Qiu, Yuan-Gang
Mao, Wei
Endothelial progenitor cells in age-related vascular remodeling
title Endothelial progenitor cells in age-related vascular remodeling
title_full Endothelial progenitor cells in age-related vascular remodeling
title_fullStr Endothelial progenitor cells in age-related vascular remodeling
title_full_unstemmed Endothelial progenitor cells in age-related vascular remodeling
title_short Endothelial progenitor cells in age-related vascular remodeling
title_sort endothelial progenitor cells in age-related vascular remodeling
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047273/
https://www.ncbi.nlm.nih.gov/pubmed/29882417
http://dx.doi.org/10.1177/0963689718779345
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AT qiuyuangang endothelialprogenitorcellsinagerelatedvascularremodeling
AT maowei endothelialprogenitorcellsinagerelatedvascularremodeling

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