Fighting against Skin Aging: The Way from Bench to Bedside

As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied...

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Detalles Bibliográficos
Autores principales: Zhang, Shoubing, Duan, Enkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/
https://www.ncbi.nlm.nih.gov/pubmed/29692196
http://dx.doi.org/10.1177/0963689717725755
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author Zhang, Shoubing
Duan, Enkui
author_facet Zhang, Shoubing
Duan, Enkui
author_sort Zhang, Shoubing
collection PubMed
description As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. In this review, we summarize these changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging.
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spelling pubmed-60472762018-07-18 Fighting against Skin Aging: The Way from Bench to Bedside Zhang, Shoubing Duan, Enkui Cell Transplant Reviews As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. In this review, we summarize these changes in skin aging, research advances of the molecular mechanisms leading to these changes, and the treatment strategies aimed at preventing or reversing skin aging. SAGE Publications 2018-04-25 2018-05 /pmc/articles/PMC6047276/ /pubmed/29692196 http://dx.doi.org/10.1177/0963689717725755 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Zhang, Shoubing
Duan, Enkui
Fighting against Skin Aging: The Way from Bench to Bedside
title Fighting against Skin Aging: The Way from Bench to Bedside
title_full Fighting against Skin Aging: The Way from Bench to Bedside
title_fullStr Fighting against Skin Aging: The Way from Bench to Bedside
title_full_unstemmed Fighting against Skin Aging: The Way from Bench to Bedside
title_short Fighting against Skin Aging: The Way from Bench to Bedside
title_sort fighting against skin aging: the way from bench to bedside
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/
https://www.ncbi.nlm.nih.gov/pubmed/29692196
http://dx.doi.org/10.1177/0963689717725755
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