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Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression

RATIONALE: Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations. AIM: Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian–auth...

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Autores principales: Lyons, Taylor, Carhart-Harris, Robin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047302/
https://www.ncbi.nlm.nih.gov/pubmed/29338538
http://dx.doi.org/10.1177/0269881117748902
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author Lyons, Taylor
Carhart-Harris, Robin L
author_facet Lyons, Taylor
Carhart-Harris, Robin L
author_sort Lyons, Taylor
collection PubMed
description RATIONALE: Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations. AIM: Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian–authoritarian political perspective in patients with treatment-resistant depression (TRD). METHODS: This open-label pilot study with a mixed-model design studied the effects of psilocybin on measures of nature relatedness and libertarian–authoritarian political perspective in patients with moderate to severe TRD (n=7) versus age-matched non-treated healthy control subjects (n=7). Psilocybin was administered in two oral dosing sessions (10 mg and 25 mg) 1 week apart. Main outcome measures were collected 1 week and 7–12 months after the second dosing session. Nature relatedness and libertarian–authoritarian political perspective were assessed using the Nature Relatedness Scale (NR-6) and Political Perspective Questionnaire (PPQ-5), respectively. RESULTS: Nature relatedness significantly increased (t(6)=−4.242, p=0.003) and authoritarianism significantly decreased (t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7–12 months post-dosing, nature relatedness remained significantly increased (t(5)=−2.707, p=0.021) and authoritarianism remained decreased at trend level (t(5)=−1.811, p=0.065). No differences were found on either measure for the non-treated healthy control subjects. CONCLUSIONS: This pilot study suggests that psilocybin with psychological support might produce lasting changes in attitudes and beliefs. Although it would be premature to infer causality from this small study, the possibility of drug-induced changes in belief systems seems sufficiently intriguing and timely to deserve further investigation.
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spelling pubmed-60473022018-07-23 Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression Lyons, Taylor Carhart-Harris, Robin L J Psychopharmacol Short Report RATIONALE: Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations. AIM: Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian–authoritarian political perspective in patients with treatment-resistant depression (TRD). METHODS: This open-label pilot study with a mixed-model design studied the effects of psilocybin on measures of nature relatedness and libertarian–authoritarian political perspective in patients with moderate to severe TRD (n=7) versus age-matched non-treated healthy control subjects (n=7). Psilocybin was administered in two oral dosing sessions (10 mg and 25 mg) 1 week apart. Main outcome measures were collected 1 week and 7–12 months after the second dosing session. Nature relatedness and libertarian–authoritarian political perspective were assessed using the Nature Relatedness Scale (NR-6) and Political Perspective Questionnaire (PPQ-5), respectively. RESULTS: Nature relatedness significantly increased (t(6)=−4.242, p=0.003) and authoritarianism significantly decreased (t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7–12 months post-dosing, nature relatedness remained significantly increased (t(5)=−2.707, p=0.021) and authoritarianism remained decreased at trend level (t(5)=−1.811, p=0.065). No differences were found on either measure for the non-treated healthy control subjects. CONCLUSIONS: This pilot study suggests that psilocybin with psychological support might produce lasting changes in attitudes and beliefs. Although it would be premature to infer causality from this small study, the possibility of drug-induced changes in belief systems seems sufficiently intriguing and timely to deserve further investigation. SAGE Publications 2018-01-17 2018-07 /pmc/articles/PMC6047302/ /pubmed/29338538 http://dx.doi.org/10.1177/0269881117748902 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Report
Lyons, Taylor
Carhart-Harris, Robin L
Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title_full Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title_fullStr Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title_full_unstemmed Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title_short Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
title_sort increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047302/
https://www.ncbi.nlm.nih.gov/pubmed/29338538
http://dx.doi.org/10.1177/0269881117748902
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