Cargando…
Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters
BACKGROUND: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 d...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047309/ https://www.ncbi.nlm.nih.gov/pubmed/30023310 http://dx.doi.org/10.1016/j.jcte.2018.05.003 |
_version_ | 1783339928970592256 |
---|---|
author | Elsaid, Nehal Hamdy Sadik, Noha Adly Ahmed, Nagwa Ramadan Fayez, Sherry Elisha Mohammed, Nagwa Abd El-Ghaffar |
author_facet | Elsaid, Nehal Hamdy Sadik, Noha Adly Ahmed, Nagwa Ramadan Fayez, Sherry Elisha Mohammed, Nagwa Abd El-Ghaffar |
author_sort | Elsaid, Nehal Hamdy |
collection | PubMed |
description | BACKGROUND: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. METHODS: The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference. Fasting (blood glucose, insulin, lipid profile, omentin-1) and HbA1c were measured. BMI and HOMA-IR were calculated. Our data analyzed and expressed in terms of mean ± SD. Pearson correlation performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups. RESULTS: We found significant decrease in serum omentin-1 levels in cases with mean ± SD (16.5 ± 2.6 pg/ml) compared to controls (25.3 ± 1.0 pg/ml) (P < 0.001). We also found strong significant negative correlations between serum omentin-1 and (BMI, fasting insulin, HOMA-IR) (r = −0.909, −0.853, −0.511) respectively (P < 0.001) and systolic blood pressure (r = −0.274, p = 0.031). The best cut off point of serum omentin-1 was 22.2 pg/ml to differentiate cases from controls using ROC curve analysis. CONCLUSION: Our study has shown significant low levels of serum omentin-1 in obese type 2 diabetic females in comparison to healthy subjects. Omentin-1 inversely related to obesity, insulin resistance and SBP. No significant associations with glycemic control and fasting lipids. Serum omentin-1 can be used as a biomarker for obesity related metabolic disorders. |
format | Online Article Text |
id | pubmed-6047309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60473092018-07-18 Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters Elsaid, Nehal Hamdy Sadik, Noha Adly Ahmed, Nagwa Ramadan Fayez, Sherry Elisha Mohammed, Nagwa Abd El-Ghaffar J Clin Transl Endocrinol Research Paper BACKGROUND: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. METHODS: The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference. Fasting (blood glucose, insulin, lipid profile, omentin-1) and HbA1c were measured. BMI and HOMA-IR were calculated. Our data analyzed and expressed in terms of mean ± SD. Pearson correlation performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups. RESULTS: We found significant decrease in serum omentin-1 levels in cases with mean ± SD (16.5 ± 2.6 pg/ml) compared to controls (25.3 ± 1.0 pg/ml) (P < 0.001). We also found strong significant negative correlations between serum omentin-1 and (BMI, fasting insulin, HOMA-IR) (r = −0.909, −0.853, −0.511) respectively (P < 0.001) and systolic blood pressure (r = −0.274, p = 0.031). The best cut off point of serum omentin-1 was 22.2 pg/ml to differentiate cases from controls using ROC curve analysis. CONCLUSION: Our study has shown significant low levels of serum omentin-1 in obese type 2 diabetic females in comparison to healthy subjects. Omentin-1 inversely related to obesity, insulin resistance and SBP. No significant associations with glycemic control and fasting lipids. Serum omentin-1 can be used as a biomarker for obesity related metabolic disorders. Elsevier 2018-05-31 /pmc/articles/PMC6047309/ /pubmed/30023310 http://dx.doi.org/10.1016/j.jcte.2018.05.003 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Elsaid, Nehal Hamdy Sadik, Noha Adly Ahmed, Nagwa Ramadan Fayez, Sherry Elisha Mohammed, Nagwa Abd El-Ghaffar Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title | Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title_full | Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title_fullStr | Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title_full_unstemmed | Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title_short | Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
title_sort | serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047309/ https://www.ncbi.nlm.nih.gov/pubmed/30023310 http://dx.doi.org/10.1016/j.jcte.2018.05.003 |
work_keys_str_mv | AT elsaidnehalhamdy serumomentin1levelsintype2diabeticobesewomeninrelationtoglycemiccontrolinsulinresistanceandmetabolicparameters AT sadiknohaadly serumomentin1levelsintype2diabeticobesewomeninrelationtoglycemiccontrolinsulinresistanceandmetabolicparameters AT ahmednagwaramadan serumomentin1levelsintype2diabeticobesewomeninrelationtoglycemiccontrolinsulinresistanceandmetabolicparameters AT fayezsherryelisha serumomentin1levelsintype2diabeticobesewomeninrelationtoglycemiccontrolinsulinresistanceandmetabolicparameters AT mohammednagwaabdelghaffar serumomentin1levelsintype2diabeticobesewomeninrelationtoglycemiccontrolinsulinresistanceandmetabolicparameters |