Multiple antiviral activities of the antimalarial and anti-hepatitis C drug candidates N-89 and N-251

The chemically synthesized endoperoxide compound N-89 and its derivative N-251 were shown to have potent antimalarial activity. We previously demonstrated that N-89 and N-251 potently inhibited the RNA replication of hepatitis C virus (HCV), which belongs to the Flaviviridae family. Since antimalari...

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Detalles Bibliográficos
Autores principales: Ueda, Youki, Gu, Weilin, Dansako, Hiromichi, Kim, Hye-Sook, Yoshizaki, Sayaka, Okumura, Nobuaki, Ishikawa, Tomohiro, Nishitsuji, Hironori, Kato, Fumihiro, Hishiki, Takayuki, Satoh, Shinya, Ishii, Koji, Masuda, Michiaki, Shimotohno, Kunitada, Ikeda, Masanori, Kato, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047365/
https://www.ncbi.nlm.nih.gov/pubmed/30023438
http://dx.doi.org/10.1016/j.bbrep.2018.05.007

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