Cargando…
Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The prese...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047483/ https://www.ncbi.nlm.nih.gov/pubmed/30023134 http://dx.doi.org/10.1016/j.jare.2018.05.012 |
_version_ | 1783339952346497024 |
---|---|
author | Nugud, Ahmed Sandeep, Divyasree El-Serafi, Ahmed T. |
author_facet | Nugud, Ahmed Sandeep, Divyasree El-Serafi, Ahmed T. |
author_sort | Nugud, Ahmed |
collection | PubMed |
description | Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of ROS levels in vitro may help in tissue regeneration studies. |
format | Online Article Text |
id | pubmed-6047483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60474832018-07-18 Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment Nugud, Ahmed Sandeep, Divyasree El-Serafi, Ahmed T. J Adv Res Review Article Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of ROS levels in vitro may help in tissue regeneration studies. Elsevier 2018-06-01 /pmc/articles/PMC6047483/ /pubmed/30023134 http://dx.doi.org/10.1016/j.jare.2018.05.012 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Nugud, Ahmed Sandeep, Divyasree El-Serafi, Ahmed T. Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title_full | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title_fullStr | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title_full_unstemmed | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title_short | Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
title_sort | two faces of the coin: minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047483/ https://www.ncbi.nlm.nih.gov/pubmed/30023134 http://dx.doi.org/10.1016/j.jare.2018.05.012 |
work_keys_str_mv | AT nugudahmed twofacesofthecoinminireviewfordissectingtheroleofreactiveoxygenspeciesinstemcellpotencyandlineagecommitment AT sandeepdivyasree twofacesofthecoinminireviewfordissectingtheroleofreactiveoxygenspeciesinstemcellpotencyandlineagecommitment AT elserafiahmedt twofacesofthecoinminireviewfordissectingtheroleofreactiveoxygenspeciesinstemcellpotencyandlineagecommitment |