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Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment

Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The prese...

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Detalles Bibliográficos
Autores principales: Nugud, Ahmed, Sandeep, Divyasree, El-Serafi, Ahmed T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047483/
https://www.ncbi.nlm.nih.gov/pubmed/30023134
http://dx.doi.org/10.1016/j.jare.2018.05.012
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author Nugud, Ahmed
Sandeep, Divyasree
El-Serafi, Ahmed T.
author_facet Nugud, Ahmed
Sandeep, Divyasree
El-Serafi, Ahmed T.
author_sort Nugud, Ahmed
collection PubMed
description Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of ROS levels in vitro may help in tissue regeneration studies.
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spelling pubmed-60474832018-07-18 Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment Nugud, Ahmed Sandeep, Divyasree El-Serafi, Ahmed T. J Adv Res Review Article Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of ROS levels in vitro may help in tissue regeneration studies. Elsevier 2018-06-01 /pmc/articles/PMC6047483/ /pubmed/30023134 http://dx.doi.org/10.1016/j.jare.2018.05.012 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Nugud, Ahmed
Sandeep, Divyasree
El-Serafi, Ahmed T.
Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title_full Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title_fullStr Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title_full_unstemmed Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title_short Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
title_sort two faces of the coin: minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047483/
https://www.ncbi.nlm.nih.gov/pubmed/30023134
http://dx.doi.org/10.1016/j.jare.2018.05.012
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