A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy

We report the first case of small bowel ulcers due to clopidogrel in a 74-year-old man. He presented with diarrhea and melena after having been taking low-dose aspirin (LDA) and clopidogrel. There was no evidence of bleeding in the stomach, duodenum, or colon. Capsule endoscopy showed multiple ulcer...

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Autores principales: Ebi, Masahide, Inoue, Satoshi, Sugiyama, Tomoya, Yamamoto, Kazuhiro, Adachi, Kazunori, Yoshimine, Takashi, Yamaguchi, Yoshiharu, Tamura, Yasuhiro, Izawa, Shinya, Hijikata, Yasutaka, Funaki, Yasushi, Ogasawara, Naotaka, Sasaki, Makoto, Kasugai, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047549/
https://www.ncbi.nlm.nih.gov/pubmed/30022920
http://dx.doi.org/10.1159/000490096
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author Ebi, Masahide
Inoue, Satoshi
Sugiyama, Tomoya
Yamamoto, Kazuhiro
Adachi, Kazunori
Yoshimine, Takashi
Yamaguchi, Yoshiharu
Tamura, Yasuhiro
Izawa, Shinya
Hijikata, Yasutaka
Funaki, Yasushi
Ogasawara, Naotaka
Sasaki, Makoto
Kasugai, Kunio
author_facet Ebi, Masahide
Inoue, Satoshi
Sugiyama, Tomoya
Yamamoto, Kazuhiro
Adachi, Kazunori
Yoshimine, Takashi
Yamaguchi, Yoshiharu
Tamura, Yasuhiro
Izawa, Shinya
Hijikata, Yasutaka
Funaki, Yasushi
Ogasawara, Naotaka
Sasaki, Makoto
Kasugai, Kunio
author_sort Ebi, Masahide
collection PubMed
description We report the first case of small bowel ulcers due to clopidogrel in a 74-year-old man. He presented with diarrhea and melena after having been taking low-dose aspirin (LDA) and clopidogrel. There was no evidence of bleeding in the stomach, duodenum, or colon. Capsule endoscopy showed multiple ulcers and erosions in the small intestine. Double-balloon endoscopy revealed multiple ulcers throughout the ileum. Examination of the biopsy specimen showed cytomegalovirus infection. His LDA was discontinued and he was prescribed ganciclovir. However, the small bowel ulcers were aggravated. Therefore, clopidogrel was discontinued. The small bowel ulcers subsequently healed completely, forming scars.
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spelling pubmed-60475492018-07-18 A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy Ebi, Masahide Inoue, Satoshi Sugiyama, Tomoya Yamamoto, Kazuhiro Adachi, Kazunori Yoshimine, Takashi Yamaguchi, Yoshiharu Tamura, Yasuhiro Izawa, Shinya Hijikata, Yasutaka Funaki, Yasushi Ogasawara, Naotaka Sasaki, Makoto Kasugai, Kunio Case Rep Gastroenterol Single Case We report the first case of small bowel ulcers due to clopidogrel in a 74-year-old man. He presented with diarrhea and melena after having been taking low-dose aspirin (LDA) and clopidogrel. There was no evidence of bleeding in the stomach, duodenum, or colon. Capsule endoscopy showed multiple ulcers and erosions in the small intestine. Double-balloon endoscopy revealed multiple ulcers throughout the ileum. Examination of the biopsy specimen showed cytomegalovirus infection. His LDA was discontinued and he was prescribed ganciclovir. However, the small bowel ulcers were aggravated. Therefore, clopidogrel was discontinued. The small bowel ulcers subsequently healed completely, forming scars. S. Karger AG 2018-06-18 /pmc/articles/PMC6047549/ /pubmed/30022920 http://dx.doi.org/10.1159/000490096 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Ebi, Masahide
Inoue, Satoshi
Sugiyama, Tomoya
Yamamoto, Kazuhiro
Adachi, Kazunori
Yoshimine, Takashi
Yamaguchi, Yoshiharu
Tamura, Yasuhiro
Izawa, Shinya
Hijikata, Yasutaka
Funaki, Yasushi
Ogasawara, Naotaka
Sasaki, Makoto
Kasugai, Kunio
A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title_full A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title_fullStr A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title_full_unstemmed A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title_short A Small Bowel Ulcer due to Clopidogrel with Cytomegalovirus Enteritis Diagnosed by Capsule and Double-Balloon Endoscopy
title_sort small bowel ulcer due to clopidogrel with cytomegalovirus enteritis diagnosed by capsule and double-balloon endoscopy
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047549/
https://www.ncbi.nlm.nih.gov/pubmed/30022920
http://dx.doi.org/10.1159/000490096
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