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Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats
Operation on the thoraco-abdominal aorta may lead to paraplegia or paraparesis is after spinal ischemia/reperfusion (I/R) injury. In this study, we investigated the protective effect of the spinach extract on spinal cord I/R injury. Thirty-five male Sprague-Dawley rats were divided into five groups:...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Urmia University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047577/ https://www.ncbi.nlm.nih.gov/pubmed/30065808 http://dx.doi.org/10.30466/VRF.2018.30825 |
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author | Farjah, Gholam Hossein Mohammad Pour, Masoumeh Khadem-Ansari, Mohammad Hassan Karimipour, Mojtaba Pourheidar, Bagher |
author_facet | Farjah, Gholam Hossein Mohammad Pour, Masoumeh Khadem-Ansari, Mohammad Hassan Karimipour, Mojtaba Pourheidar, Bagher |
author_sort | Farjah, Gholam Hossein |
collection | PubMed |
description | Operation on the thoraco-abdominal aorta may lead to paraplegia or paraparesis is after spinal ischemia/reperfusion (I/R) injury. In this study, we investigated the protective effect of the spinach extract on spinal cord I/R injury. Thirty-five male Sprague-Dawley rats were divided into five groups: Intact, sham surgery, normal saline (NS), low dose spinach extract (20 mg kg(-1)), high dose spinach extract (50 mg kg(-1)). Neurological function, biochemical and histological evaluations were performed in 72 hr after ischemia. The mean motor deficit index scores of the spinach extract groups were significantly lower than in the NS group at 72hr after spinal cord ischemia. In addition, Spinach extract groups significantly increased plasma level of total antioxidative capacity and decreased the plasma level of malondialdehyde than the NS group. The spinach extract groups displayed a significantly large number of normal motor neurons compared with the NS group. In conclusion, the present study showed that the spinach extract may preserve more neurons in a rat model of spinal cord I/R injury. |
format | Online Article Text |
id | pubmed-6047577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Urmia University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60475772018-07-31 Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats Farjah, Gholam Hossein Mohammad Pour, Masoumeh Khadem-Ansari, Mohammad Hassan Karimipour, Mojtaba Pourheidar, Bagher Vet Res Forum Short Communication Operation on the thoraco-abdominal aorta may lead to paraplegia or paraparesis is after spinal ischemia/reperfusion (I/R) injury. In this study, we investigated the protective effect of the spinach extract on spinal cord I/R injury. Thirty-five male Sprague-Dawley rats were divided into five groups: Intact, sham surgery, normal saline (NS), low dose spinach extract (20 mg kg(-1)), high dose spinach extract (50 mg kg(-1)). Neurological function, biochemical and histological evaluations were performed in 72 hr after ischemia. The mean motor deficit index scores of the spinach extract groups were significantly lower than in the NS group at 72hr after spinal cord ischemia. In addition, Spinach extract groups significantly increased plasma level of total antioxidative capacity and decreased the plasma level of malondialdehyde than the NS group. The spinach extract groups displayed a significantly large number of normal motor neurons compared with the NS group. In conclusion, the present study showed that the spinach extract may preserve more neurons in a rat model of spinal cord I/R injury. Urmia University Press 2018 2018-06-15 /pmc/articles/PMC6047577/ /pubmed/30065808 http://dx.doi.org/10.30466/VRF.2018.30825 Text en © 2018 Urmia University. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Short Communication Farjah, Gholam Hossein Mohammad Pour, Masoumeh Khadem-Ansari, Mohammad Hassan Karimipour, Mojtaba Pourheidar, Bagher Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title | Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title_full | Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title_fullStr | Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title_full_unstemmed | Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title_short | Protective effect of aqueous spinach (Spinacia oleracea L.) extract on spinal cord ischemia-reperfusion injury in rats |
title_sort | protective effect of aqueous spinach (spinacia oleracea l.) extract on spinal cord ischemia-reperfusion injury in rats |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047577/ https://www.ncbi.nlm.nih.gov/pubmed/30065808 http://dx.doi.org/10.30466/VRF.2018.30825 |
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