The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

We demonstrate here that the G protein-coupled receptor (GPCR), sphingosine 1-phosphate receptor 2 (S1P(2), Mr = 40 kDa) is shed in hsp70(+) and CD63(+) containing exosomes from MDA-MB-231 breast cancer cells. The receptor is taken up by fibroblasts, where it is N-terminally processed to a shorter f...

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Detalles Bibliográficos
Autores principales: El Buri, Ashref, Adams, David R., Smith, Douglas, Tate, Rothwelle J., Mullin, Margaret, Pyne, Susan, Pyne, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047680/
https://www.ncbi.nlm.nih.gov/pubmed/30034630
http://dx.doi.org/10.18632/oncotarget.25658

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