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A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder

BACKGROUND: Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) struc...

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Autores principales: Yamada, Satoshi, Nakao, Tomohiro, Ikari, Keisuke, Kuwano, Masumi, Murayama, Keitaro, Tomiyama, Hirofumi, Hasuzawa, Suguru, Togao, Osamu, Hiwatashi, Akio, Kanba, Shigenobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047811/
https://www.ncbi.nlm.nih.gov/pubmed/30011337
http://dx.doi.org/10.1371/journal.pone.0200814
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author Yamada, Satoshi
Nakao, Tomohiro
Ikari, Keisuke
Kuwano, Masumi
Murayama, Keitaro
Tomiyama, Hirofumi
Hasuzawa, Suguru
Togao, Osamu
Hiwatashi, Akio
Kanba, Shigenobu
author_facet Yamada, Satoshi
Nakao, Tomohiro
Ikari, Keisuke
Kuwano, Masumi
Murayama, Keitaro
Tomiyama, Hirofumi
Hasuzawa, Suguru
Togao, Osamu
Hiwatashi, Akio
Kanba, Shigenobu
author_sort Yamada, Satoshi
collection PubMed
description BACKGROUND: Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. METHODS: Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. RESULTS: The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p<0.05) in both Brodmann area (BA)10 and BA11. There was no significant difference between OCD and healthy control groups. No significant correlation between the clinical data including age of onset, symptom severity score, and GM volume was observed in HD and OCD groups. CONCLUSIONS: The results might help to explain the inconsistency of previous studies. As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.
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spelling pubmed-60478112018-07-26 A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder Yamada, Satoshi Nakao, Tomohiro Ikari, Keisuke Kuwano, Masumi Murayama, Keitaro Tomiyama, Hirofumi Hasuzawa, Suguru Togao, Osamu Hiwatashi, Akio Kanba, Shigenobu PLoS One Research Article BACKGROUND: Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. METHODS: Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. RESULTS: The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p<0.05) in both Brodmann area (BA)10 and BA11. There was no significant difference between OCD and healthy control groups. No significant correlation between the clinical data including age of onset, symptom severity score, and GM volume was observed in HD and OCD groups. CONCLUSIONS: The results might help to explain the inconsistency of previous studies. As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD. Public Library of Science 2018-07-16 /pmc/articles/PMC6047811/ /pubmed/30011337 http://dx.doi.org/10.1371/journal.pone.0200814 Text en © 2018 Yamada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamada, Satoshi
Nakao, Tomohiro
Ikari, Keisuke
Kuwano, Masumi
Murayama, Keitaro
Tomiyama, Hirofumi
Hasuzawa, Suguru
Togao, Osamu
Hiwatashi, Akio
Kanba, Shigenobu
A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title_full A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title_fullStr A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title_full_unstemmed A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title_short A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
title_sort unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047811/
https://www.ncbi.nlm.nih.gov/pubmed/30011337
http://dx.doi.org/10.1371/journal.pone.0200814
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