Cargando…
Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate
Cyclophosphamide (CYA), also known as cytophosphane, is a medication used as a chemotherapeutic agent and immune suppressor.Its common adverse effects include nausea, vomiting, diarrhea, bone marrow suppression, hemorrhagic cystitis, alopecia, lethargy, and cardiotoxicity. Cyclophosphamide-related c...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047839/ https://www.ncbi.nlm.nih.gov/pubmed/30034955 http://dx.doi.org/10.7759/cureus.2633 |
_version_ | 1783340000634470400 |
---|---|
author | Ejaz, Komal Raza, Muhammad A Maroof, Shahram Haider, Muhammad W |
author_facet | Ejaz, Komal Raza, Muhammad A Maroof, Shahram Haider, Muhammad W |
author_sort | Ejaz, Komal |
collection | PubMed |
description | Cyclophosphamide (CYA), also known as cytophosphane, is a medication used as a chemotherapeutic agent and immune suppressor.Its common adverse effects include nausea, vomiting, diarrhea, bone marrow suppression, hemorrhagic cystitis, alopecia, lethargy, and cardiotoxicity. Cyclophosphamide-related cardiac toxicity is not uncommon and causes potentially serious complications in patients. In this review, we present a case of a 65-years-old patient who developed atrial fibrillation with rapid ventricular rate (RVR) after receiving a single dose of CYA. In this case, the advanced age of the patient, pre-treatment with prednisone, and renal insufficiency most likely predisposed the patient to CYA-induced cardiac toxicity. A relevant literature review was also conducted to determine the pathogenesis, risk factors, and spectrum of CYA-induced cardiac toxicity. |
format | Online Article Text |
id | pubmed-6047839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-60478392018-07-20 Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate Ejaz, Komal Raza, Muhammad A Maroof, Shahram Haider, Muhammad W Cureus Cardiology Cyclophosphamide (CYA), also known as cytophosphane, is a medication used as a chemotherapeutic agent and immune suppressor.Its common adverse effects include nausea, vomiting, diarrhea, bone marrow suppression, hemorrhagic cystitis, alopecia, lethargy, and cardiotoxicity. Cyclophosphamide-related cardiac toxicity is not uncommon and causes potentially serious complications in patients. In this review, we present a case of a 65-years-old patient who developed atrial fibrillation with rapid ventricular rate (RVR) after receiving a single dose of CYA. In this case, the advanced age of the patient, pre-treatment with prednisone, and renal insufficiency most likely predisposed the patient to CYA-induced cardiac toxicity. A relevant literature review was also conducted to determine the pathogenesis, risk factors, and spectrum of CYA-induced cardiac toxicity. Cureus 2018-05-16 /pmc/articles/PMC6047839/ /pubmed/30034955 http://dx.doi.org/10.7759/cureus.2633 Text en Copyright © 2018, Ejaz et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Ejaz, Komal Raza, Muhammad A Maroof, Shahram Haider, Muhammad W Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title | Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title_full | Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title_fullStr | Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title_full_unstemmed | Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title_short | Cyclophosphamide-induced Atrial Fibrillation With Rapid Ventricular Rate |
title_sort | cyclophosphamide-induced atrial fibrillation with rapid ventricular rate |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047839/ https://www.ncbi.nlm.nih.gov/pubmed/30034955 http://dx.doi.org/10.7759/cureus.2633 |
work_keys_str_mv | AT ejazkomal cyclophosphamideinducedatrialfibrillationwithrapidventricularrate AT razamuhammada cyclophosphamideinducedatrialfibrillationwithrapidventricularrate AT maroofshahram cyclophosphamideinducedatrialfibrillationwithrapidventricularrate AT haidermuhammadw cyclophosphamideinducedatrialfibrillationwithrapidventricularrate |