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Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography

BACKGROUND: The (18)F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, (18)F-THK-5351 can also monitor neuroinflammatory process due to high affinity to astrogliosis. We a...

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Autores principales: Huang, Kuo-Lun, Hsu, Jung-Lung, Lin, Kun-Ju, Chang, Chien-Hung, Wu, Yi-Ming, Chang, Ting-Yu, Chang, Yeu-Jhy, Liu, Chi-Hung, Ho, Meng-Yang, Wey, Shiaw-Pyng, Yen, Tzu-Chen, Okamura, Nobuyuki, Hsiao, Ing-Tsung, Lee, Tsong-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047954/
https://www.ncbi.nlm.nih.gov/pubmed/30014313
http://dx.doi.org/10.1186/s13550-018-0417-1
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author Huang, Kuo-Lun
Hsu, Jung-Lung
Lin, Kun-Ju
Chang, Chien-Hung
Wu, Yi-Ming
Chang, Ting-Yu
Chang, Yeu-Jhy
Liu, Chi-Hung
Ho, Meng-Yang
Wey, Shiaw-Pyng
Yen, Tzu-Chen
Okamura, Nobuyuki
Hsiao, Ing-Tsung
Lee, Tsong-Hai
author_facet Huang, Kuo-Lun
Hsu, Jung-Lung
Lin, Kun-Ju
Chang, Chien-Hung
Wu, Yi-Ming
Chang, Ting-Yu
Chang, Yeu-Jhy
Liu, Chi-Hung
Ho, Meng-Yang
Wey, Shiaw-Pyng
Yen, Tzu-Chen
Okamura, Nobuyuki
Hsiao, Ing-Tsung
Lee, Tsong-Hai
author_sort Huang, Kuo-Lun
collection PubMed
description BACKGROUND: The (18)F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, (18)F-THK-5351 can also monitor neuroinflammatory process due to high affinity to astrogliosis. We aimed to explore (18)F-THK-5351 distribution patterns and characteristics in patients with recent ischemic stroke. RESULTS: Fifteen patients received (18)F-THK-5351 positron emission tomography (PET) and diffusion tensor imaging (DTI) approximately 3 months after ischemic stroke. A region of interest (ROI) was placed in the peri-ischemic area and was mirrored on the contralateral side as the control, and a proportional value was derived from the ratio of the peri-ischemic ROI value over the mirrored ROI value. Increased (18)F-THK-5351 retention was observed in the areas around and remote from the stroke location. The proportional (18)F-THK-5351 values were negatively correlated with the proportional fractional anisotropy values (r = − 0.39, P = 0.04). CONCLUSION: (18)F-THK-5351 PET imaging provides a potential tool for in vivo visualization of the widespread ischemia-related changes associated with a microstructural disruption in recent ischemic stroke patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13550-018-0417-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-60479542018-08-02 Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography Huang, Kuo-Lun Hsu, Jung-Lung Lin, Kun-Ju Chang, Chien-Hung Wu, Yi-Ming Chang, Ting-Yu Chang, Yeu-Jhy Liu, Chi-Hung Ho, Meng-Yang Wey, Shiaw-Pyng Yen, Tzu-Chen Okamura, Nobuyuki Hsiao, Ing-Tsung Lee, Tsong-Hai EJNMMI Res Original Research BACKGROUND: The (18)F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, (18)F-THK-5351 can also monitor neuroinflammatory process due to high affinity to astrogliosis. We aimed to explore (18)F-THK-5351 distribution patterns and characteristics in patients with recent ischemic stroke. RESULTS: Fifteen patients received (18)F-THK-5351 positron emission tomography (PET) and diffusion tensor imaging (DTI) approximately 3 months after ischemic stroke. A region of interest (ROI) was placed in the peri-ischemic area and was mirrored on the contralateral side as the control, and a proportional value was derived from the ratio of the peri-ischemic ROI value over the mirrored ROI value. Increased (18)F-THK-5351 retention was observed in the areas around and remote from the stroke location. The proportional (18)F-THK-5351 values were negatively correlated with the proportional fractional anisotropy values (r = − 0.39, P = 0.04). CONCLUSION: (18)F-THK-5351 PET imaging provides a potential tool for in vivo visualization of the widespread ischemia-related changes associated with a microstructural disruption in recent ischemic stroke patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13550-018-0417-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-07-16 /pmc/articles/PMC6047954/ /pubmed/30014313 http://dx.doi.org/10.1186/s13550-018-0417-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Huang, Kuo-Lun
Hsu, Jung-Lung
Lin, Kun-Ju
Chang, Chien-Hung
Wu, Yi-Ming
Chang, Ting-Yu
Chang, Yeu-Jhy
Liu, Chi-Hung
Ho, Meng-Yang
Wey, Shiaw-Pyng
Yen, Tzu-Chen
Okamura, Nobuyuki
Hsiao, Ing-Tsung
Lee, Tsong-Hai
Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title_full Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title_fullStr Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title_full_unstemmed Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title_short Visualization of ischemic stroke-related changes on (18)F-THK-5351 positron emission tomography
title_sort visualization of ischemic stroke-related changes on (18)f-thk-5351 positron emission tomography
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047954/
https://www.ncbi.nlm.nih.gov/pubmed/30014313
http://dx.doi.org/10.1186/s13550-018-0417-1
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