Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum

A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin...

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Autores principales: Tokunaga, Mami, Nanjo, Sohachi, Yoshita, Hiroki, Fujinami, Haruka, Watanabe, Tohru, Ishii, Yoko, Kobayashi, Saito, Akashi, Momoko, Takagi, Hiroaki, Mihara, Hiroshi, Kajiura, Shinya, Ando, Takayuki, Hashimoto, Isaya, Hojo, Shozo, Okumura, Tomoyuki, Sugiyama, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047988/
https://www.ncbi.nlm.nih.gov/pubmed/29434135
http://dx.doi.org/10.2169/internalmedicine.0229-17
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author Tokunaga, Mami
Nanjo, Sohachi
Yoshita, Hiroki
Fujinami, Haruka
Watanabe, Tohru
Ishii, Yoko
Kobayashi, Saito
Akashi, Momoko
Takagi, Hiroaki
Mihara, Hiroshi
Kajiura, Shinya
Ando, Takayuki
Hashimoto, Isaya
Hojo, Shozo
Okumura, Tomoyuki
Sugiyama, Toshiro
author_facet Tokunaga, Mami
Nanjo, Sohachi
Yoshita, Hiroki
Fujinami, Haruka
Watanabe, Tohru
Ishii, Yoko
Kobayashi, Saito
Akashi, Momoko
Takagi, Hiroaki
Mihara, Hiroshi
Kajiura, Shinya
Ando, Takayuki
Hashimoto, Isaya
Hojo, Shozo
Okumura, Tomoyuki
Sugiyama, Toshiro
author_sort Tokunaga, Mami
collection PubMed
description A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.
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spelling pubmed-60479882018-07-17 Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum Tokunaga, Mami Nanjo, Sohachi Yoshita, Hiroki Fujinami, Haruka Watanabe, Tohru Ishii, Yoko Kobayashi, Saito Akashi, Momoko Takagi, Hiroaki Mihara, Hiroshi Kajiura, Shinya Ando, Takayuki Hashimoto, Isaya Hojo, Shozo Okumura, Tomoyuki Sugiyama, Toshiro Intern Med Case Report A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum. The Japanese Society of Internal Medicine 2018-02-09 2018-06-15 /pmc/articles/PMC6047988/ /pubmed/29434135 http://dx.doi.org/10.2169/internalmedicine.0229-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tokunaga, Mami
Nanjo, Sohachi
Yoshita, Hiroki
Fujinami, Haruka
Watanabe, Tohru
Ishii, Yoko
Kobayashi, Saito
Akashi, Momoko
Takagi, Hiroaki
Mihara, Hiroshi
Kajiura, Shinya
Ando, Takayuki
Hashimoto, Isaya
Hojo, Shozo
Okumura, Tomoyuki
Sugiyama, Toshiro
Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title_full Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title_fullStr Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title_full_unstemmed Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title_short Multiple Synchronous Sporadic Gastrointestinal Stromal Tumors in the Stomach and Jejunum
title_sort multiple synchronous sporadic gastrointestinal stromal tumors in the stomach and jejunum
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047988/
https://www.ncbi.nlm.nih.gov/pubmed/29434135
http://dx.doi.org/10.2169/internalmedicine.0229-17
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