Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory

The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutio...

Descripción completa

Detalles Bibliográficos
Autores principales: Aqrabawi, Afif J., Kim, Jun Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048034/
https://www.ncbi.nlm.nih.gov/pubmed/30013078
http://dx.doi.org/10.1038/s41467-018-05131-6
_version_ 1783340028460531712
author Aqrabawi, Afif J.
Kim, Jun Chul
author_facet Aqrabawi, Afif J.
Kim, Jun Chul
author_sort Aqrabawi, Afif J.
collection PubMed
description The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory.
format Online
Article
Text
id pubmed-6048034
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-60480342018-07-18 Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory Aqrabawi, Afif J. Kim, Jun Chul Nat Commun Article The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory. Nature Publishing Group UK 2018-07-16 /pmc/articles/PMC6048034/ /pubmed/30013078 http://dx.doi.org/10.1038/s41467-018-05131-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Aqrabawi, Afif J.
Kim, Jun Chul
Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title_full Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title_fullStr Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title_full_unstemmed Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title_short Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
title_sort hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048034/
https://www.ncbi.nlm.nih.gov/pubmed/30013078
http://dx.doi.org/10.1038/s41467-018-05131-6
work_keys_str_mv AT aqrabawiafifj hippocampalprojectionstotheanteriorolfactorynucleusdifferentiallyconveyspatiotemporalinformationduringepisodicodourmemory
AT kimjunchul hippocampalprojectionstotheanteriorolfactorynucleusdifferentiallyconveyspatiotemporalinformationduringepisodicodourmemory

Ejemplares similares