Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice

The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. I...

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Detalles Bibliográficos
Autores principales: Yang, Chun, Larin, Andrei, McKenna, James T., Jacobson, Kenneth A., Winston, Stuart, Strecker, Robert E., Kalinchuk, Anna, Basheer, Radhika, Brown, Ritchie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048041/
https://www.ncbi.nlm.nih.gov/pubmed/30013200
http://dx.doi.org/10.1038/s41598-018-29103-4

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