Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) a...

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Detalles Bibliográficos
Autores principales: Asada, Shuhei, Goyama, Susumu, Inoue, Daichi, Shikata, Shiori, Takeda, Reina, Fukushima, Tsuyoshi, Yonezawa, Taishi, Fujino, Takeshi, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Fukuyama, Tomofusa, Tanaka, Yosuke, Yokoyama, Akihiko, Yamazaki, Satoshi, Kozuka-Hata, Hiroko, Oyama, Masaaki, Kojima, Shinya, Kawazu, Masahito, Mano, Hiroyuki, Kitamura, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048047/
https://www.ncbi.nlm.nih.gov/pubmed/30013160
http://dx.doi.org/10.1038/s41467-018-05085-9

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