TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Metastatic lung cancer is the leading cause of cancer-associated mortality worldwide, therefore necessitating novel approaches to identify specific genetic drivers for lung cancer progression and metastasis. We recently performed an in vivo gain-of-function genetic screen to identify driver genes of...

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Detalles Bibliográficos
Autores principales: Kundu, Samrat T., Grzeskowiak, Caitlin L., Fradette, Jared J., Gibson, Laura A., Rodriguez, Leticia B., Creighton, Chad J., Scott, Kenneth L., Gibbons, Don L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048095/
https://www.ncbi.nlm.nih.gov/pubmed/30013069
http://dx.doi.org/10.1038/s41467-018-05013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048095/
https://www.ncbi.nlm.nih.gov/pubmed/30013069
http://dx.doi.org/10.1038/s41467-018-05013-x

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