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Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that Act1 functions as a negative regulator in T and B cells via direct...

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Detalles Bibliográficos
Autores principales:	Zhang, Cun-Jin, Wang, Chenhui, Jiang, Meiling, Gu, Chunfang, Xiao, Jianxin, Chen, Xing, Martin, Bradley N., Tang, Fangqiang, Yamamoto, Erin, Xian, Yibo, Wang, Han, Li, Fengling, Sartor, R. Balfour, Smith, Howard, Husni, M. Elaine, Shi, Fu-Dong, Gao, Ji, Carman, Julie, Dongre, Ashok, McKarns, Susan C., Coppieters, Ken, Jørgensen, Trine N., Leonard, Warren J., Li, Xiaoxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048100/ https://www.ncbi.nlm.nih.gov/pubmed/30013031 http://dx.doi.org/10.1038/s41467-018-04974-3

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