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High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer
BACKGROUND: Matrix metalloproteinase-8 (MMP-8) is a protease mainly expressed by neutrophils that cleaves numerous substrates, including collagens and cytokines. We have previously shown that serum MMP-8 levels increase in colorectal cancer (CRC) and correlate with distant metastasis. However, short...
Autores principales: | Sirniö, Päivi, Tuomisto, Anne, Tervahartiala, Taina, Sorsa, Timo, Klintrup, Kai, Karhu, Toni, Herzig, Karl-Heinz, Mäkelä, Jyrki, Karttunen, Tuomo J., Salo, Tuula, Mäkinen, Markus J., Väyrynen, Juha P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048114/ https://www.ncbi.nlm.nih.gov/pubmed/29808017 http://dx.doi.org/10.1038/s41416-018-0136-4 |
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