Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation

Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the dynamic interplay between the malignant cell populations and their stromal fibroblasts are important de...

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Autores principales: Valcz, Gábor, Buzás, Edit Irén, Szállási, Zoltán, Kalmár, Alexandra, Krenács, Tibor, Tulassay, Zsolt, Igaz, Péter, Molnár, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048124/
https://www.ncbi.nlm.nih.gov/pubmed/30038960
http://dx.doi.org/10.1038/s41523-018-0071-9
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author Valcz, Gábor
Buzás, Edit Irén
Szállási, Zoltán
Kalmár, Alexandra
Krenács, Tibor
Tulassay, Zsolt
Igaz, Péter
Molnár, Béla
author_facet Valcz, Gábor
Buzás, Edit Irén
Szállási, Zoltán
Kalmár, Alexandra
Krenács, Tibor
Tulassay, Zsolt
Igaz, Péter
Molnár, Béla
author_sort Valcz, Gábor
collection PubMed
description Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the dynamic interplay between the malignant cell populations and their stromal fibroblasts are important determinants of metastatic tumor invasion. Important mediators of these interactions are the small, membrane-enclosed extracellular vesicles, in particular exosomes. Both cancer cell and fibroblast-derived exosomes carry a set of regulatory molecules, including proteins and different species of RNA, which cooperatively support metastatic tumor spread. Here, we briefly overview potential links between cancer stem cells and the exosome-mediated fibroblast-enriched metastatic niche formation to discuss their role in the promotion of tumor growth and metastatic expansion in breast carcinoma models.
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spelling pubmed-60481242018-07-23 Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation Valcz, Gábor Buzás, Edit Irén Szállási, Zoltán Kalmár, Alexandra Krenács, Tibor Tulassay, Zsolt Igaz, Péter Molnár, Béla NPJ Breast Cancer Review Article Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the dynamic interplay between the malignant cell populations and their stromal fibroblasts are important determinants of metastatic tumor invasion. Important mediators of these interactions are the small, membrane-enclosed extracellular vesicles, in particular exosomes. Both cancer cell and fibroblast-derived exosomes carry a set of regulatory molecules, including proteins and different species of RNA, which cooperatively support metastatic tumor spread. Here, we briefly overview potential links between cancer stem cells and the exosome-mediated fibroblast-enriched metastatic niche formation to discuss their role in the promotion of tumor growth and metastatic expansion in breast carcinoma models. Nature Publishing Group UK 2018-07-16 /pmc/articles/PMC6048124/ /pubmed/30038960 http://dx.doi.org/10.1038/s41523-018-0071-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Valcz, Gábor
Buzás, Edit Irén
Szállási, Zoltán
Kalmár, Alexandra
Krenács, Tibor
Tulassay, Zsolt
Igaz, Péter
Molnár, Béla
Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title_full Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title_fullStr Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title_full_unstemmed Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title_short Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
title_sort perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048124/
https://www.ncbi.nlm.nih.gov/pubmed/30038960
http://dx.doi.org/10.1038/s41523-018-0071-9
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